Metabolic syndrome and the role of dietary lifestyles in Alzheimer's disease
Since Alzheimer's disease (AD) has no cure or preventive treatment, an urgent need exists to find a means of preventing, delaying the onset, or reversing the course of the disease. Clinical and epidemiological evidence suggests that lifestyle factors, especially nutrition, may be crucial in con...
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| Veröffentlicht in: | Journal of neurochemistry 2008-08, Vol.106 (4), p.1503-1514 |
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| description | Since Alzheimer's disease (AD) has no cure or preventive treatment, an urgent need exists to find a means of preventing, delaying the onset, or reversing the course of the disease. Clinical and epidemiological evidence suggests that lifestyle factors, especially nutrition, may be crucial in controlling AD. Unhealthy lifestyle choices lead to an increasing incidence of obesity, dyslipidemia and hypertension - components of the metabolic syndrome. These disorders can also be linked to AD. Recent research supports the hypothesis that calorie intake, among other non-genetic factors, can influence the risk of clinical dementia. In animal studies, high calorie intake in the form of saturated fat promoted AD-type amyloidosis, while calorie restriction via reduced carbohydrate intake prevented it. Pending further study, it is prudent to recommend to those at risk for AD - e.g. with a family history or features of metabolic syndrome, such as obesity, insulin insensitivity, etc. - to avoid foods and beverages with added sugars; to eat whole, unrefined foods with natural fats, especially fish, nuts and seeds, olives and olive oil; and to minimize foods that disrupt insulin and blood sugar balance. |
| doi_str_mv | 10.1111/j.1471-4159.2008.05454.x |
| format | Article |
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Clinical and epidemiological evidence suggests that lifestyle factors, especially nutrition, may be crucial in controlling AD. Unhealthy lifestyle choices lead to an increasing incidence of obesity, dyslipidemia and hypertension - components of the metabolic syndrome. These disorders can also be linked to AD. Recent research supports the hypothesis that calorie intake, among other non-genetic factors, can influence the risk of clinical dementia. In animal studies, high calorie intake in the form of saturated fat promoted AD-type amyloidosis, while calorie restriction via reduced carbohydrate intake prevented it. Pending further study, it is prudent to recommend to those at risk for AD - e.g. with a family history or features of metabolic syndrome, such as obesity, insulin insensitivity, etc. - to avoid foods and beverages with added sugars; to eat whole, unrefined foods with natural fats, especially fish, nuts and seeds, olives and olive oil; and to minimize foods that disrupt insulin and blood sugar balance.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1111/j.1471-4159.2008.05454.x</identifier><identifier>PMID: 18466323</identifier><identifier>CODEN: JONRA9</identifier><language>eng</language><publisher>Oxford, UK: Oxford, UK : Blackwell Publishing Ltd</publisher><subject>Alzheimer disease ; Alzheimer Disease - diet therapy ; Alzheimer Disease - etiology ; Alzheimer Disease - prevention & control ; Alzheimers disease ; Alzheimer’s disease ; Animals ; Biochemistry ; Biological and medical sciences ; calorie restriction ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; diabetes ; diet ; Diet - adverse effects ; Humans ; insulin ; ketogenic diet ; Life Style ; Medical sciences ; Metabolic diseases ; Metabolic syndrome ; Metabolic Syndrome - complications ; Metabolic Syndrome - diet therapy ; Miscellaneous ; Neurology ; Nutrition ; obesity ; Olea ; Other metabolic disorders</subject><ispartof>Journal of neurochemistry, 2008-08, Vol.106 (4), p.1503-1514</ispartof><rights>2008 The Authors. 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Clinical and epidemiological evidence suggests that lifestyle factors, especially nutrition, may be crucial in controlling AD. Unhealthy lifestyle choices lead to an increasing incidence of obesity, dyslipidemia and hypertension - components of the metabolic syndrome. These disorders can also be linked to AD. Recent research supports the hypothesis that calorie intake, among other non-genetic factors, can influence the risk of clinical dementia. In animal studies, high calorie intake in the form of saturated fat promoted AD-type amyloidosis, while calorie restriction via reduced carbohydrate intake prevented it. Pending further study, it is prudent to recommend to those at risk for AD - e.g. with a family history or features of metabolic syndrome, such as obesity, insulin insensitivity, etc. - to avoid foods and beverages with added sugars; to eat whole, unrefined foods with natural fats, especially fish, nuts and seeds, olives and olive oil; and to minimize foods that disrupt insulin and blood sugar balance.</description><subject>Alzheimer disease</subject><subject>Alzheimer Disease - diet therapy</subject><subject>Alzheimer Disease - etiology</subject><subject>Alzheimer Disease - prevention & control</subject><subject>Alzheimers disease</subject><subject>Alzheimer’s disease</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>calorie restriction</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>diabetes</subject><subject>diet</subject><subject>Diet - adverse effects</subject><subject>Humans</subject><subject>insulin</subject><subject>ketogenic diet</subject><subject>Life Style</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - complications</subject><subject>Metabolic Syndrome - diet therapy</subject><subject>Miscellaneous</subject><subject>Neurology</subject><subject>Nutrition</subject><subject>obesity</subject><subject>Olea</subject><subject>Other metabolic disorders</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUuP0zAUhS0EYkrhL4CFBKwS_I6zAGlU8VSBBczactybqSsnHuwWpvx6nGlVHhvwxpbud67PvQchTElNy3m-qaloaCWobGtGiK6JFFLU17fQ7FS4jWaEMFZxItgZupfzhhCqhKJ30RnVQinO-AwtP8DWdjF4h_N-XKU4ALbjCm_XgFMMgGOPV74waY-D7yFv9wEy9iM-Dz_W4AdIz3IhMtgM99Gd3oYMD473HF28fvVl8bZafnrzbnG-rJySRFSutRIYWNV3rGFOqV45bnXTCRBAOaFSaNkS3knHFQdhBWFOU6lFw22rgM_Ry0Pfq103wMrBuE02mKvkh-LTROvNn5XRr81l_GaY1A1pRGnw9Nggxa-7MpQZfHYQgh0h7rJRLW-1pvyfIG1Fwcou5-jxX-Am7tJYtmAYUSUddQPpA-RSzDlBf7JMiZmCNRsz5Wem_MwUrLkJ1lwX6cPfR_4lPCZZgCdHwGZnQ5_s6Hw-cYzIRikyeXhx4L77APv_NmDef1xMr6J_dND3Nhp7mcofF58ZKbGRtmyDc_4TutDG7w</recordid><startdate>200808</startdate><enddate>200808</enddate><creator>Pasinetti, Giulio Maria</creator><creator>Eberstein, Jacqueline A</creator><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200808</creationdate><title>Metabolic syndrome and the role of dietary lifestyles in Alzheimer's disease</title><author>Pasinetti, Giulio Maria ; Eberstein, Jacqueline A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6504-c9a5e2ea6fb272c66f6c3a87b4e4e13015485903b5c363e4a402c8158473a96e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Alzheimer disease</topic><topic>Alzheimer Disease - diet therapy</topic><topic>Alzheimer Disease - etiology</topic><topic>Alzheimer Disease - prevention & control</topic><topic>Alzheimers disease</topic><topic>Alzheimer’s disease</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>calorie restriction</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. 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Clinical and epidemiological evidence suggests that lifestyle factors, especially nutrition, may be crucial in controlling AD. Unhealthy lifestyle choices lead to an increasing incidence of obesity, dyslipidemia and hypertension - components of the metabolic syndrome. These disorders can also be linked to AD. Recent research supports the hypothesis that calorie intake, among other non-genetic factors, can influence the risk of clinical dementia. In animal studies, high calorie intake in the form of saturated fat promoted AD-type amyloidosis, while calorie restriction via reduced carbohydrate intake prevented it. Pending further study, it is prudent to recommend to those at risk for AD - e.g. with a family history or features of metabolic syndrome, such as obesity, insulin insensitivity, etc. - to avoid foods and beverages with added sugars; to eat whole, unrefined foods with natural fats, especially fish, nuts and seeds, olives and olive oil; and to minimize foods that disrupt insulin and blood sugar balance.</abstract><cop>Oxford, UK</cop><pub>Oxford, UK : Blackwell Publishing Ltd</pub><pmid>18466323</pmid><doi>10.1111/j.1471-4159.2008.05454.x</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alzheimer disease Alzheimer Disease - diet therapy Alzheimer Disease - etiology Alzheimer Disease - prevention & control Alzheimers disease Alzheimer’s disease Animals Biochemistry Biological and medical sciences calorie restriction Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases diabetes diet Diet - adverse effects Humans insulin ketogenic diet Life Style Medical sciences Metabolic diseases Metabolic syndrome Metabolic Syndrome - complications Metabolic Syndrome - diet therapy Miscellaneous Neurology Nutrition obesity Olea Other metabolic disorders |
| title | Metabolic syndrome and the role of dietary lifestyles in Alzheimer's disease |
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