Identifying Autism Loci and Genes by Tracing Recent Shared Ancestry

To find inherited causes of autism-spectrum disorders, we studied families in which parents share ancestors, enhancing the role of inherited factors. We mapped several loci, some containing large, inherited, homozygous deletions that are likely mutations. The largest deletions implicated genes, incl...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2008-07, Vol.321 (5886), p.218-223
Hauptverfasser:	Morrow, Eric M, Yoo, Seung-Yun, Flavell, Steven W, Kim, Tae-Kyung, Lin, Yingxi, Hill, Robert Sean, Mukaddes, Nahit M, Balkhy, Soher, Gascon, Generoso, Hashmi, Asif, Al-Saad, Samira, Ware, Janice, Joseph, Robert M, Greenblatt, Rachel, Gleason, Danielle, Ertelt, Julia A, Apse, Kira A, Bodell, Adria, Partlow, Jennifer N, Barry, Brenda, Yao, Hui, Markianos, Kyriacos, Ferland, Russell J, Greenberg, Michael E, Walsh, Christopher A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Animals Autism Autistic disorder Autistic Disorder - genetics Autistic Disorder - physiopathology Biological and medical sciences Biomedical research Brain - metabolism Cadherins - genetics Child clinical studies Chromosome Mapping Classical genetics, quantitative genetics, hybrids Consanguinity Depolarization Developmental disorders Epilepsy Female Formins Fundamental and applied biological sciences. Psychology Gene Deletion Gene Dosage Gene expression Gene Expression Regulation Genes Genes, Recessive Genetic heterogeneity Genetic inheritance Genetic loci Genetic mutation Genetic Predisposition to Disease Genetics Genetics of eukaryotes. Biological and molecular evolution Homozygote Human Humans Infantile autism Lod Score Male Medical genetics Medical sciences Mutation Neurons - physiology Nonsense Oligonucleotide Array Sequence Analysis Pedigree Polymorphism, Single Nucleotide Protocadherins Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Rats Research Article Sodium-Hydrogen Exchangers - genetics Transcription Factors - genetics Transcription Factors - metabolism
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