Tooth Loss and Lack of Regular Oral Hygiene Are Associated with Higher Risk of Esophageal Squamous Cell Carcinoma
We tested the association between tooth loss and oral hygiene and the risk of esophageal squamous cell carcinoma (ESCC) in people living in a high-risk area of Iran. We used a case-control study of pathologically confirmed ESCC cases ( n = 283) and controls ( n = 560) matched on sex, age, and neighb...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2008-11, Vol.17 (11), p.3062-3068 |
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| creator | Abnet, Christian C Kamangar, Farin Islami, Farhad Nasrollahzadeh, Dariush Brennan, Paul Aghcheli, Karim Merat, Shahin Pourshams, Akram Marjani, Haj Amin Ebadati, Abdolhakim Sotoudeh, Masoud Boffetta, Paolo Malekzadeh, Reza Dawsey, Sanford M |
| description | We tested the association between tooth loss and oral hygiene and the risk of esophageal squamous cell carcinoma (ESCC) in
people living in a high-risk area of Iran. We used a case-control study of pathologically confirmed ESCC cases ( n = 283) and controls ( n = 560) matched on sex, age, and neighborhood. Subjects with ESCC had significantly more decayed, missing, or filled teeth
(DMFT) with a median (interquartile range) of 31 (23-32) compared with controls 28 (16-32; P = 0.0045). Subjects with ESCC were significantly more likely than controls to fail to practice regular oral hygiene (78%
versus 58%). In multivariate-adjusted conditional logistic regression models, having 32 DMFT compared with ≤15 conferred an
odds ratio (95% confidence interval) of 2.10 (1.19-3.70). Compared with daily tooth brushing, practicing no regular oral hygiene
conferred an odds ratio (95% confidence interval) of 2.37 (1.42-3.97). Restricting the analysis to subjects that had never
smoked tobacco did not materially alter these results. We found significant associations between two markers of poor oral
hygiene, a larger number of DMFT and lack of daily tooth brushing, and risk of ESCC in a population at high risk for ESCC
where many cases occur in never smokers. Our results are consistent with several previous analyses in other high-risk populations.
(Cancer Epidemiol Biomarkers Prev 2008;17(11):3062–8) |
| doi_str_mv | 10.1158/1055-9965.EPI-08-0558 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2586052</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69760084</sourcerecordid><originalsourceid>FETCH-LOGICAL-c495t-ed696e08d37663d14575927b22293389f422946c8af568d94652401a11d355f73</originalsourceid><addsrcrecordid>eNpVUU1v1DAUtBCIlsJPAPmExCHFTvL8cUGqVgtbaaWiUs6W6ziJIYl37YSq_5637PJ1sPwsz4w9M4S85uySc1DvOQMotBZwuf58XTBV4Fk9IeccKlVICfAU59-YM_Ii52-MMakBnpMzrrRmspbnZH8X49zTbcyZ2qmhW-u-09jSW98tg030JtmBbh674CdPrxKunKMLdvYNfQjI3ISu94nehvyLt85x19vOI-vLfrFjXDJd-WGgK5tcmOJoX5JnrR2yf3XaL8jXj-u71abY3ny6Xl1tC1drmAvfCC08U00lhagaXoMEXcr7six1VSnd1jjUwinbglANjlDWjFvOmwqgldUF-XDU3S33o2-cn2b0YnYpjDY9mmiD-f9mCr3p4g9TghIMShR4exJIcb_4PJsxZIde7OTRlhFaCsZUjUA4Al3CGJNv_zzCmTmUZQ5FmEMRBssyTJlDWch78-8P_7JO7SDg3RHQY8gPIXnj7OR8Sj57jLM3XKK-qZgoq5_1dZ5U</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69760084</pqid></control><display><type>article</type><title>Tooth Loss and Lack of Regular Oral Hygiene Are Associated with Higher Risk of Esophageal Squamous Cell Carcinoma</title><source>MEDLINE</source><source>American Association for Cancer Research</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Abnet, Christian C ; Kamangar, Farin ; Islami, Farhad ; Nasrollahzadeh, Dariush ; Brennan, Paul ; Aghcheli, Karim ; Merat, Shahin ; Pourshams, Akram ; Marjani, Haj Amin ; Ebadati, Abdolhakim ; Sotoudeh, Masoud ; Boffetta, Paolo ; Malekzadeh, Reza ; Dawsey, Sanford M</creator><creatorcontrib>Abnet, Christian C ; Kamangar, Farin ; Islami, Farhad ; Nasrollahzadeh, Dariush ; Brennan, Paul ; Aghcheli, Karim ; Merat, Shahin ; Pourshams, Akram ; Marjani, Haj Amin ; Ebadati, Abdolhakim ; Sotoudeh, Masoud ; Boffetta, Paolo ; Malekzadeh, Reza ; Dawsey, Sanford M</creatorcontrib><description>We tested the association between tooth loss and oral hygiene and the risk of esophageal squamous cell carcinoma (ESCC) in
people living in a high-risk area of Iran. We used a case-control study of pathologically confirmed ESCC cases ( n = 283) and controls ( n = 560) matched on sex, age, and neighborhood. Subjects with ESCC had significantly more decayed, missing, or filled teeth
(DMFT) with a median (interquartile range) of 31 (23-32) compared with controls 28 (16-32; P = 0.0045). Subjects with ESCC were significantly more likely than controls to fail to practice regular oral hygiene (78%
versus 58%). In multivariate-adjusted conditional logistic regression models, having 32 DMFT compared with ≤15 conferred an
odds ratio (95% confidence interval) of 2.10 (1.19-3.70). Compared with daily tooth brushing, practicing no regular oral hygiene
conferred an odds ratio (95% confidence interval) of 2.37 (1.42-3.97). Restricting the analysis to subjects that had never
smoked tobacco did not materially alter these results. We found significant associations between two markers of poor oral
hygiene, a larger number of DMFT and lack of daily tooth brushing, and risk of ESCC in a population at high risk for ESCC
where many cases occur in never smokers. Our results are consistent with several previous analyses in other high-risk populations.
(Cancer Epidemiol Biomarkers Prev 2008;17(11):3062–8)</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-08-0558</identifier><identifier>PMID: 18990747</identifier><language>eng</language><publisher>United States: American Association for Cancer Research</publisher><subject>Aged ; cancer ; Carcinoma, Squamous Cell - epidemiology ; Carcinoma, Squamous Cell - etiology ; Case-Control Studies ; Chi-Square Distribution ; Esophageal Neoplasms - epidemiology ; Esophageal Neoplasms - etiology ; esophagus ; Female ; Humans ; Iran - epidemiology ; Logistic Models ; Male ; Middle Aged ; Oral Health ; Physical Examination ; Precancerous Conditions ; Risk Factors ; squamous ; Surveys and Questionnaires ; tooth brushing ; tooth loss ; Tooth Loss - complications</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2008-11, Vol.17 (11), p.3062-3068</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-ed696e08d37663d14575927b22293389f422946c8af568d94652401a11d355f73</citedby><cites>FETCH-LOGICAL-c495t-ed696e08d37663d14575927b22293389f422946c8af568d94652401a11d355f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,3343,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18990747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abnet, Christian C</creatorcontrib><creatorcontrib>Kamangar, Farin</creatorcontrib><creatorcontrib>Islami, Farhad</creatorcontrib><creatorcontrib>Nasrollahzadeh, Dariush</creatorcontrib><creatorcontrib>Brennan, Paul</creatorcontrib><creatorcontrib>Aghcheli, Karim</creatorcontrib><creatorcontrib>Merat, Shahin</creatorcontrib><creatorcontrib>Pourshams, Akram</creatorcontrib><creatorcontrib>Marjani, Haj Amin</creatorcontrib><creatorcontrib>Ebadati, Abdolhakim</creatorcontrib><creatorcontrib>Sotoudeh, Masoud</creatorcontrib><creatorcontrib>Boffetta, Paolo</creatorcontrib><creatorcontrib>Malekzadeh, Reza</creatorcontrib><creatorcontrib>Dawsey, Sanford M</creatorcontrib><title>Tooth Loss and Lack of Regular Oral Hygiene Are Associated with Higher Risk of Esophageal Squamous Cell Carcinoma</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>We tested the association between tooth loss and oral hygiene and the risk of esophageal squamous cell carcinoma (ESCC) in
people living in a high-risk area of Iran. We used a case-control study of pathologically confirmed ESCC cases ( n = 283) and controls ( n = 560) matched on sex, age, and neighborhood. Subjects with ESCC had significantly more decayed, missing, or filled teeth
(DMFT) with a median (interquartile range) of 31 (23-32) compared with controls 28 (16-32; P = 0.0045). Subjects with ESCC were significantly more likely than controls to fail to practice regular oral hygiene (78%
versus 58%). In multivariate-adjusted conditional logistic regression models, having 32 DMFT compared with ≤15 conferred an
odds ratio (95% confidence interval) of 2.10 (1.19-3.70). Compared with daily tooth brushing, practicing no regular oral hygiene
conferred an odds ratio (95% confidence interval) of 2.37 (1.42-3.97). Restricting the analysis to subjects that had never
smoked tobacco did not materially alter these results. We found significant associations between two markers of poor oral
hygiene, a larger number of DMFT and lack of daily tooth brushing, and risk of ESCC in a population at high risk for ESCC
where many cases occur in never smokers. Our results are consistent with several previous analyses in other high-risk populations.
(Cancer Epidemiol Biomarkers Prev 2008;17(11):3062–8)</description><subject>Aged</subject><subject>cancer</subject><subject>Carcinoma, Squamous Cell - epidemiology</subject><subject>Carcinoma, Squamous Cell - etiology</subject><subject>Case-Control Studies</subject><subject>Chi-Square Distribution</subject><subject>Esophageal Neoplasms - epidemiology</subject><subject>Esophageal Neoplasms - etiology</subject><subject>esophagus</subject><subject>Female</subject><subject>Humans</subject><subject>Iran - epidemiology</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oral Health</subject><subject>Physical Examination</subject><subject>Precancerous Conditions</subject><subject>Risk Factors</subject><subject>squamous</subject><subject>Surveys and Questionnaires</subject><subject>tooth brushing</subject><subject>tooth loss</subject><subject>Tooth Loss - complications</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUU1v1DAUtBCIlsJPAPmExCHFTvL8cUGqVgtbaaWiUs6W6ziJIYl37YSq_5637PJ1sPwsz4w9M4S85uySc1DvOQMotBZwuf58XTBV4Fk9IeccKlVICfAU59-YM_Ii52-MMakBnpMzrrRmspbnZH8X49zTbcyZ2qmhW-u-09jSW98tg030JtmBbh674CdPrxKunKMLdvYNfQjI3ISu94nehvyLt85x19vOI-vLfrFjXDJd-WGgK5tcmOJoX5JnrR2yf3XaL8jXj-u71abY3ny6Xl1tC1drmAvfCC08U00lhagaXoMEXcr7six1VSnd1jjUwinbglANjlDWjFvOmwqgldUF-XDU3S33o2-cn2b0YnYpjDY9mmiD-f9mCr3p4g9TghIMShR4exJIcb_4PJsxZIde7OTRlhFaCsZUjUA4Al3CGJNv_zzCmTmUZQ5FmEMRBssyTJlDWch78-8P_7JO7SDg3RHQY8gPIXnj7OR8Sj57jLM3XKK-qZgoq5_1dZ5U</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>Abnet, Christian C</creator><creator>Kamangar, Farin</creator><creator>Islami, Farhad</creator><creator>Nasrollahzadeh, Dariush</creator><creator>Brennan, Paul</creator><creator>Aghcheli, Karim</creator><creator>Merat, Shahin</creator><creator>Pourshams, Akram</creator><creator>Marjani, Haj Amin</creator><creator>Ebadati, Abdolhakim</creator><creator>Sotoudeh, Masoud</creator><creator>Boffetta, Paolo</creator><creator>Malekzadeh, Reza</creator><creator>Dawsey, Sanford M</creator><general>American Association for Cancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20081101</creationdate><title>Tooth Loss and Lack of Regular Oral Hygiene Are Associated with Higher Risk of Esophageal Squamous Cell Carcinoma</title><author>Abnet, Christian C ; Kamangar, Farin ; Islami, Farhad ; Nasrollahzadeh, Dariush ; Brennan, Paul ; Aghcheli, Karim ; Merat, Shahin ; Pourshams, Akram ; Marjani, Haj Amin ; Ebadati, Abdolhakim ; Sotoudeh, Masoud ; Boffetta, Paolo ; Malekzadeh, Reza ; Dawsey, Sanford M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-ed696e08d37663d14575927b22293389f422946c8af568d94652401a11d355f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>cancer</topic><topic>Carcinoma, Squamous Cell - epidemiology</topic><topic>Carcinoma, Squamous Cell - etiology</topic><topic>Case-Control Studies</topic><topic>Chi-Square Distribution</topic><topic>Esophageal Neoplasms - epidemiology</topic><topic>Esophageal Neoplasms - etiology</topic><topic>esophagus</topic><topic>Female</topic><topic>Humans</topic><topic>Iran - epidemiology</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oral Health</topic><topic>Physical Examination</topic><topic>Precancerous Conditions</topic><topic>Risk Factors</topic><topic>squamous</topic><topic>Surveys and Questionnaires</topic><topic>tooth brushing</topic><topic>tooth loss</topic><topic>Tooth Loss - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abnet, Christian C</creatorcontrib><creatorcontrib>Kamangar, Farin</creatorcontrib><creatorcontrib>Islami, Farhad</creatorcontrib><creatorcontrib>Nasrollahzadeh, Dariush</creatorcontrib><creatorcontrib>Brennan, Paul</creatorcontrib><creatorcontrib>Aghcheli, Karim</creatorcontrib><creatorcontrib>Merat, Shahin</creatorcontrib><creatorcontrib>Pourshams, Akram</creatorcontrib><creatorcontrib>Marjani, Haj Amin</creatorcontrib><creatorcontrib>Ebadati, Abdolhakim</creatorcontrib><creatorcontrib>Sotoudeh, Masoud</creatorcontrib><creatorcontrib>Boffetta, Paolo</creatorcontrib><creatorcontrib>Malekzadeh, Reza</creatorcontrib><creatorcontrib>Dawsey, Sanford M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abnet, Christian C</au><au>Kamangar, Farin</au><au>Islami, Farhad</au><au>Nasrollahzadeh, Dariush</au><au>Brennan, Paul</au><au>Aghcheli, Karim</au><au>Merat, Shahin</au><au>Pourshams, Akram</au><au>Marjani, Haj Amin</au><au>Ebadati, Abdolhakim</au><au>Sotoudeh, Masoud</au><au>Boffetta, Paolo</au><au>Malekzadeh, Reza</au><au>Dawsey, Sanford M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tooth Loss and Lack of Regular Oral Hygiene Are Associated with Higher Risk of Esophageal Squamous Cell Carcinoma</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>17</volume><issue>11</issue><spage>3062</spage><epage>3068</epage><pages>3062-3068</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>We tested the association between tooth loss and oral hygiene and the risk of esophageal squamous cell carcinoma (ESCC) in
people living in a high-risk area of Iran. We used a case-control study of pathologically confirmed ESCC cases ( n = 283) and controls ( n = 560) matched on sex, age, and neighborhood. Subjects with ESCC had significantly more decayed, missing, or filled teeth
(DMFT) with a median (interquartile range) of 31 (23-32) compared with controls 28 (16-32; P = 0.0045). Subjects with ESCC were significantly more likely than controls to fail to practice regular oral hygiene (78%
versus 58%). In multivariate-adjusted conditional logistic regression models, having 32 DMFT compared with ≤15 conferred an
odds ratio (95% confidence interval) of 2.10 (1.19-3.70). Compared with daily tooth brushing, practicing no regular oral hygiene
conferred an odds ratio (95% confidence interval) of 2.37 (1.42-3.97). Restricting the analysis to subjects that had never
smoked tobacco did not materially alter these results. We found significant associations between two markers of poor oral
hygiene, a larger number of DMFT and lack of daily tooth brushing, and risk of ESCC in a population at high risk for ESCC
where many cases occur in never smokers. Our results are consistent with several previous analyses in other high-risk populations.
(Cancer Epidemiol Biomarkers Prev 2008;17(11):3062–8)</abstract><cop>United States</cop><pub>American Association for Cancer Research</pub><pmid>18990747</pmid><doi>10.1158/1055-9965.EPI-08-0558</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1055-9965 |
| ispartof | Cancer epidemiology, biomarkers & prevention, 2008-11, Vol.17 (11), p.3062-3068 |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2586052 |
| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aged cancer Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - etiology Case-Control Studies Chi-Square Distribution Esophageal Neoplasms - epidemiology Esophageal Neoplasms - etiology esophagus Female Humans Iran - epidemiology Logistic Models Male Middle Aged Oral Health Physical Examination Precancerous Conditions Risk Factors squamous Surveys and Questionnaires tooth brushing tooth loss Tooth Loss - complications |
| title | Tooth Loss and Lack of Regular Oral Hygiene Are Associated with Higher Risk of Esophageal Squamous Cell Carcinoma |
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