Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism

Mutation of Bcr-Abl is an important mechanism by which chronic myelogenous leukemia (CML) cells become resistant to Gleevec. The T315I mutation is clinically significant since CML cells harboring this mutation are insensitive to Gleevec and other Bcr-Abl-targeted drugs. Identification of new agents...

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Veröffentlicht in:	Leukemia 2008-06, Vol.22 (6), p.1191-1199
Hauptverfasser:	Zhang, H, Trachootham, D, Lu, W, Carew, J, Giles, F J, Keating, M J, Arlinghaus, R B, Huang, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Dehydrogenase - antagonists & inhibitors Animals Anticarcinogenic Agents - pharmacology Antineoplastic Agents - pharmacology Antioxidants Antioxidants - pharmacology Apoptosis - drug effects BCR-ABL protein Benzamides Biological and medical sciences Cancer Research Cancer therapies Caspase 3 - metabolism Caspase-3 Cell activation Cell death Cells, Cultured Chromosome aberrations Chronic myeloid leukemia Critical Care Medicine Cytotoxicity Degradation Dosage and administration Drug resistance Drug Resistance, Neoplasm Drug therapy Enzyme Activation - drug effects Fusion protein Fusion Proteins, bcr-abl - genetics Fusion Proteins, bcr-abl - metabolism Gene mutations Genetic aspects Glutathione - metabolism Health aspects Hematologic and hematopoietic diseases Hematology Humans Imatinib Mesylate Immunoblotting Inhibitor drugs Intensive Internal Medicine Isothiocyanate Isothiocyanates - therapeutic use Kinases Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical genetics Medical sciences Medicine Medicine & Public Health Mice Mutation Mutation - genetics Myeloid leukemia Oncology original-article Oxidation-Reduction Oxidative stress Piperazines - pharmacology Precursor Cells, B-Lymphoid - drug effects Precursor Cells, B-Lymphoid - metabolism Proteasomes Protein-tyrosine kinase Protein-Tyrosine Kinases - antagonists & inhibitors Proteins Pyrimidines - pharmacology Reactive Oxygen Species - metabolism Targeted cancer therapy Thiocyanates Tumor cell lines
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