Giant Glial Cell: New Insight Through Mechanism-Based Modeling
The paper describes a detailed mechanism-based model of a tripartite synapse consisting of P- and R-neurons together with a giant glial cell in the ganglia of the medical leech (Hirudo medicinalis), which is a useful object for experimental studies in situ. We describe the two main pathways of the g...
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| Veröffentlicht in: | Journal of biological physics 2008-08, Vol.34 (3-4), p.441-457 |
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| container_issue | 3-4 |
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| container_title | Journal of biological physics |
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| creator | Postnov, D. E Ryazanova, L. S Brazhe, N. A Brazhe, A. R Maximov, G. V Mosekilde, E Sosnovtseva, O. V |
| description | The paper describes a detailed mechanism-based model of a tripartite synapse consisting of P- and R-neurons together with a giant glial cell in the ganglia of the medical leech (Hirudo medicinalis), which is a useful object for experimental studies in situ. We describe the two main pathways of the glial cell activation: (1) via IP₃ production and Ca² ⁺ release from the endoplasmic reticulum and (2) via increase of the extracellular potassium concentration, glia depolarization, and opening of voltage-dependent Ca² ⁺ channels. We suggest that the second pathway is the more significant for establishing the positive feedback in glutamate release that is critical for the self-sustained activity of the postsynaptic neuron. This mechanism differs from the mechanisms of the astrocyte-neuron signaling previously reported. |
| doi_str_mv | 10.1007/s10867-008-9070-7 |
| format | Article |
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This mechanism differs from the mechanisms of the astrocyte-neuron signaling previously reported.</description><identifier>ISSN: 0092-0606</identifier><identifier>EISSN: 1573-0689</identifier><identifier>DOI: 10.1007/s10867-008-9070-7</identifier><identifier>PMID: 19669488</identifier><language>eng</language><publisher>Dordrecht: Dordrecht : Springer Netherlands</publisher><subject>Biochemistry ; Biological and Medical Physics ; Biophysics ; Cellular biology ; Complex Fluids and Microfluidics ; Complex Systems ; Glia ; Hirudinea ; Hirudo medicinalis ; Neuron ; Neurons ; Neurosciences ; Original Paper ; Physics ; Physics and Astronomy ; Soft and Granular Matter ; Tripartite synapse</subject><ispartof>Journal of biological physics, 2008-08, Vol.34 (3-4), p.441-457</ispartof><rights>Springer Science + Business Media B.V. 2008</rights><rights>Springer Science+Business Media B.V. 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c523t-974dbe15557017cf4b9fecdf30283fb67e1dd4ed03b6c8689c3d62b862769d693</citedby><cites>FETCH-LOGICAL-c523t-974dbe15557017cf4b9fecdf30283fb67e1dd4ed03b6c8689c3d62b862769d693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585624/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585624/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19669488$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Postnov, D. E</creatorcontrib><creatorcontrib>Ryazanova, L. S</creatorcontrib><creatorcontrib>Brazhe, N. A</creatorcontrib><creatorcontrib>Brazhe, A. R</creatorcontrib><creatorcontrib>Maximov, G. V</creatorcontrib><creatorcontrib>Mosekilde, E</creatorcontrib><creatorcontrib>Sosnovtseva, O. V</creatorcontrib><title>Giant Glial Cell: New Insight Through Mechanism-Based Modeling</title><title>Journal of biological physics</title><addtitle>J Biol Phys</addtitle><addtitle>J Biol Phys</addtitle><description>The paper describes a detailed mechanism-based model of a tripartite synapse consisting of P- and R-neurons together with a giant glial cell in the ganglia of the medical leech (Hirudo medicinalis), which is a useful object for experimental studies in situ. 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| source | Open Access: PubMed Central; springer (창간호~2014); Free E-Journal (出版社公開部分のみ） |
| subjects | Biochemistry Biological and Medical Physics Biophysics Cellular biology Complex Fluids and Microfluidics Complex Systems Glia Hirudinea Hirudo medicinalis Neuron Neurons Neurosciences Original Paper Physics Physics and Astronomy Soft and Granular Matter Tripartite synapse |
| title | Giant Glial Cell: New Insight Through Mechanism-Based Modeling |
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