Proinflammatory cytokines tumor necrosis factor-alpha and interferon-gamma alter tight junction structure and function in the rat parotid gland Par-C10 cell line

Sjögren's syndrome (SS) is an autoimmune disorder characterized by inflammation and dysfunction of salivary glands, resulting in impaired secretory function. The production of the proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) is elevated in e...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2008-11, Vol.295 (5), p.C1191-C1201
Hauptverfasser:	Baker, Olga J, Camden, Jean M, Redman, Robert S, Jones, Jonathan E, Seye, Cheikh I, Erb, Laurie, Weisman, Gary A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Carbachol - pharmacology Cell Line, Transformed Cell Shape Claudin-1 Electric Impedance Inflammation Mediators - metabolism Interferon-gamma - metabolism Membrane Proteins - metabolism Muscarinic Agonists - pharmacology Parotid Gland - cytology Parotid Gland - drug effects Parotid Gland - immunology Parotid Gland - ultrastructure Permeability Rats Receptors and Signal Transduction Receptors, Purinergic P2 - metabolism Receptors, Purinergic P2Y2 Saliva - metabolism Tight Junctions - drug effects Tight Junctions - immunology Tight Junctions - ultrastructure Time Factors Tumor Necrosis Factor-alpha - metabolism Uridine Triphosphate - metabolism
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