Prevention of traumatic headache, dizziness and fatigue with creatine administration. A pilot study
Aim: The complex pathobiology of traumatic brain injury (TBI) offers numerous targets for potential neuroprotective agents. We evaluate the clinical benefit after creatine (Cr) administration in children and adolescents Methods: A prospective, randomized, comparative, open‐ labelled pilot study of t...
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| Veröffentlicht in: | Acta Paediatrica 2008-01, Vol.97 (1), p.31-34 |
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| creator | Sakellaris, George Nasis, George Kotsiou, Maria Tamiolaki, Maria Charissis, Giorgos Evangeliou, Athanasios |
| description | Aim: The complex pathobiology of traumatic brain injury (TBI) offers numerous targets for potential neuroprotective agents. We evaluate the clinical benefit after creatine (Cr) administration in children and adolescents
Methods: A prospective, randomized, comparative, open‐ labelled pilot study of the possible neuroprotective effect of Cr was carried out on 39 children and adolescents, aged between 1 and 18 years of age, with TBI. The Cr was administered for 6 months, at a dose of 0.4 g/kg in an oral suspension form every day. For categorical variables, we used the Chi‐square test to identify differences between controls and cases. Statistical significance was defined as a p‐value < 0.05 and not statistically significant if p‐value > 0.1.
Results: The administration of Cr to children and adolescents with TBI improved results in several parameters, including duration of post traumatic amnesia (PTA), duration of intubation, intensive care unit stay. Significant improvement was recorded in the categories of headache (p < 0.001), dizziness (p = 0.005) and fatigue (p < 0.001), aspects in all patients. No side effects were seen due to Cr administration.
Conclusion: More specific examinations including brain spectroscopy for in vivo evaluation of Cr can be done, in order to draw conclusions for the optimal duration and manner of Cr supply, as well as its possible role for the prevention of TBI complications, in double blind studies. |
| doi_str_mv | 10.1111/j.1651-2227.2007.00529.x |
| format | Article |
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Methods: A prospective, randomized, comparative, open‐ labelled pilot study of the possible neuroprotective effect of Cr was carried out on 39 children and adolescents, aged between 1 and 18 years of age, with TBI. The Cr was administered for 6 months, at a dose of 0.4 g/kg in an oral suspension form every day. For categorical variables, we used the Chi‐square test to identify differences between controls and cases. Statistical significance was defined as a p‐value < 0.05 and not statistically significant if p‐value > 0.1.
Results: The administration of Cr to children and adolescents with TBI improved results in several parameters, including duration of post traumatic amnesia (PTA), duration of intubation, intensive care unit stay. Significant improvement was recorded in the categories of headache (p < 0.001), dizziness (p = 0.005) and fatigue (p < 0.001), aspects in all patients. No side effects were seen due to Cr administration.
Conclusion: More specific examinations including brain spectroscopy for in vivo evaluation of Cr can be done, in order to draw conclusions for the optimal duration and manner of Cr supply, as well as its possible role for the prevention of TBI complications, in double blind studies.</description><identifier>ISSN: 0803-5253</identifier><identifier>EISSN: 1651-2227</identifier><identifier>DOI: 10.1111/j.1651-2227.2007.00529.x</identifier><identifier>PMID: 18053002</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Biological and medical sciences ; Brain Injuries - complications ; Case-Control Studies ; Child ; Child, Preschool ; Creatine - therapeutic use ; Dizziness - etiology ; Dizziness - prevention & control ; Fatigue - etiology ; Fatigue - prevention & control ; General aspects ; Humans ; Infant ; Length of Stay ; Medical sciences ; Miscellaneous ; Neuroprotective Agents - therapeutic use ; Pilot Projects ; Post-Traumatic Headache - prevention & control ; Prevention and actions ; Prospective Studies ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Regular ; Time Factors ; Treatment Outcome</subject><ispartof>Acta Paediatrica, 2008-01, Vol.97 (1), p.31-34</ispartof><rights>2007 The Author(s)/Journal Compilation © 2007 Foundation Acta Pædiatrica</rights><rights>2008 INIST-CNRS</rights><rights>2007 The Author(s)/Journal Compilation © 2007 Foundation Acta Pædiatrica/Acta Pædiatrica 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5709-447765e6e5afde7aef4974efe325e1975b0960df42a74d5e6799186b57c9c9893</citedby><cites>FETCH-LOGICAL-c5709-447765e6e5afde7aef4974efe325e1975b0960df42a74d5e6799186b57c9c9893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1651-2227.2007.00529.x$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1651-2227.2007.00529.x$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19998162$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18053002$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakellaris, George</creatorcontrib><creatorcontrib>Nasis, George</creatorcontrib><creatorcontrib>Kotsiou, Maria</creatorcontrib><creatorcontrib>Tamiolaki, Maria</creatorcontrib><creatorcontrib>Charissis, Giorgos</creatorcontrib><creatorcontrib>Evangeliou, Athanasios</creatorcontrib><title>Prevention of traumatic headache, dizziness and fatigue with creatine administration. A pilot study</title><title>Acta Paediatrica</title><addtitle>Acta Paediatr</addtitle><description>Aim: The complex pathobiology of traumatic brain injury (TBI) offers numerous targets for potential neuroprotective agents. We evaluate the clinical benefit after creatine (Cr) administration in children and adolescents
Methods: A prospective, randomized, comparative, open‐ labelled pilot study of the possible neuroprotective effect of Cr was carried out on 39 children and adolescents, aged between 1 and 18 years of age, with TBI. The Cr was administered for 6 months, at a dose of 0.4 g/kg in an oral suspension form every day. For categorical variables, we used the Chi‐square test to identify differences between controls and cases. Statistical significance was defined as a p‐value < 0.05 and not statistically significant if p‐value > 0.1.
Results: The administration of Cr to children and adolescents with TBI improved results in several parameters, including duration of post traumatic amnesia (PTA), duration of intubation, intensive care unit stay. Significant improvement was recorded in the categories of headache (p < 0.001), dizziness (p = 0.005) and fatigue (p < 0.001), aspects in all patients. No side effects were seen due to Cr administration.
Conclusion: More specific examinations including brain spectroscopy for in vivo evaluation of Cr can be done, in order to draw conclusions for the optimal duration and manner of Cr supply, as well as its possible role for the prevention of TBI complications, in double blind studies.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Brain Injuries - complications</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Creatine - therapeutic use</subject><subject>Dizziness - etiology</subject><subject>Dizziness - prevention & control</subject><subject>Fatigue - etiology</subject><subject>Fatigue - prevention & control</subject><subject>General aspects</subject><subject>Humans</subject><subject>Infant</subject><subject>Length of Stay</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Neuroprotective Agents - therapeutic use</subject><subject>Pilot Projects</subject><subject>Post-Traumatic Headache - prevention & control</subject><subject>Prevention and actions</subject><subject>Prospective Studies</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Regular</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0803-5253</issn><issn>1651-2227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNqNkVtvEzEQhS1ERdPCX0B-gafu1pf1ei0hpCiUgtRCESD6Zjne2cZhL8HebZP-erxNlMIT-GU8mu8czegghClJaXyny5TmgiaMMZkyQmRKiGAqXT9Bk_3gKZqQgvBEMMEP0VEIS0IYV1n-DB3Sggge2wmyVx5uoe1d1-Kuwr03Q2N6Z_ECTGnsAk5w6e7vXQshYNOWuIrTmwHwnesX2HqIbQvYlI1rXYjy0SnFU7xyddfj0A_l5jk6qEwd4MWuHqPv78--zT4kF5_PP86mF4kVkqgky6TMBeQgTFWCNFBlSmZQAWcCqJJiTlROyipjRmZlBKVStMjnQlplVaH4MXq79V0N8wZKG8_yptYr7xrjN7ozTv89ad1C33S3momCc5VHg9c7A9_9GiD0unHBQl2bFrohaEkYFVwW_wQZUSJ6iggWW9D6LgQP1X4bSvQYpV7qMTE9JqbHKPVDlHodpS__vOZRuMsuAq92gAnW1JU3rXXhkVNKFTQfuTdb7s7VsPnvBfT0aho_UZ5s5TFeWO_lxv_UueRS6B-fznX27uv17PLLtVb8N1ecyrY</recordid><startdate>200801</startdate><enddate>200801</enddate><creator>Sakellaris, George</creator><creator>Nasis, George</creator><creator>Kotsiou, Maria</creator><creator>Tamiolaki, Maria</creator><creator>Charissis, Giorgos</creator><creator>Evangeliou, Athanasios</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>24P</scope><scope>WIN</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200801</creationdate><title>Prevention of traumatic headache, dizziness and fatigue with creatine administration. A pilot study</title><author>Sakellaris, George ; Nasis, George ; Kotsiou, Maria ; Tamiolaki, Maria ; Charissis, Giorgos ; Evangeliou, Athanasios</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5709-447765e6e5afde7aef4974efe325e1975b0960df42a74d5e6799186b57c9c9893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Brain Injuries - complications</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Creatine - therapeutic use</topic><topic>Dizziness - etiology</topic><topic>Dizziness - prevention & control</topic><topic>Fatigue - etiology</topic><topic>Fatigue - prevention & control</topic><topic>General aspects</topic><topic>Humans</topic><topic>Infant</topic><topic>Length of Stay</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Neuroprotective Agents - therapeutic use</topic><topic>Pilot Projects</topic><topic>Post-Traumatic Headache - prevention & control</topic><topic>Prevention and actions</topic><topic>Prospective Studies</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Regular</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakellaris, George</creatorcontrib><creatorcontrib>Nasis, George</creatorcontrib><creatorcontrib>Kotsiou, Maria</creatorcontrib><creatorcontrib>Tamiolaki, Maria</creatorcontrib><creatorcontrib>Charissis, Giorgos</creatorcontrib><creatorcontrib>Evangeliou, Athanasios</creatorcontrib><collection>Istex</collection><collection>Wiley Online Library Open Access</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta Paediatrica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakellaris, George</au><au>Nasis, George</au><au>Kotsiou, Maria</au><au>Tamiolaki, Maria</au><au>Charissis, Giorgos</au><au>Evangeliou, Athanasios</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevention of traumatic headache, dizziness and fatigue with creatine administration. A pilot study</atitle><jtitle>Acta Paediatrica</jtitle><addtitle>Acta Paediatr</addtitle><date>2008-01</date><risdate>2008</risdate><volume>97</volume><issue>1</issue><spage>31</spage><epage>34</epage><pages>31-34</pages><issn>0803-5253</issn><eissn>1651-2227</eissn><abstract>Aim: The complex pathobiology of traumatic brain injury (TBI) offers numerous targets for potential neuroprotective agents. We evaluate the clinical benefit after creatine (Cr) administration in children and adolescents
Methods: A prospective, randomized, comparative, open‐ labelled pilot study of the possible neuroprotective effect of Cr was carried out on 39 children and adolescents, aged between 1 and 18 years of age, with TBI. The Cr was administered for 6 months, at a dose of 0.4 g/kg in an oral suspension form every day. For categorical variables, we used the Chi‐square test to identify differences between controls and cases. Statistical significance was defined as a p‐value < 0.05 and not statistically significant if p‐value > 0.1.
Results: The administration of Cr to children and adolescents with TBI improved results in several parameters, including duration of post traumatic amnesia (PTA), duration of intubation, intensive care unit stay. Significant improvement was recorded in the categories of headache (p < 0.001), dizziness (p = 0.005) and fatigue (p < 0.001), aspects in all patients. No side effects were seen due to Cr administration.
Conclusion: More specific examinations including brain spectroscopy for in vivo evaluation of Cr can be done, in order to draw conclusions for the optimal duration and manner of Cr supply, as well as its possible role for the prevention of TBI complications, in double blind studies.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18053002</pmid><doi>10.1111/j.1651-2227.2007.00529.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Biological and medical sciences Brain Injuries - complications Case-Control Studies Child Child, Preschool Creatine - therapeutic use Dizziness - etiology Dizziness - prevention & control Fatigue - etiology Fatigue - prevention & control General aspects Humans Infant Length of Stay Medical sciences Miscellaneous Neuroprotective Agents - therapeutic use Pilot Projects Post-Traumatic Headache - prevention & control Prevention and actions Prospective Studies Public health. Hygiene Public health. Hygiene-occupational medicine Regular Time Factors Treatment Outcome |
| title | Prevention of traumatic headache, dizziness and fatigue with creatine administration. A pilot study |
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