The biologic properties of leukemias arising from BCR/ABL-mediated transformation vary as a function of developmental origin and activity of the p19ARF gene

Recent reports have shown that upon expression of appropriate oncogenes, both stem cells and more differentiated progenitor populations can serve as leukemia-initiating cells. These studies suggest that oncogenic mutations subvert normal development and induce reacquisition of stem-like features. Ho...

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Veröffentlicht in:	Blood 2008-11, Vol.112 (10), p.4184-4192
Hauptverfasser:	Wang, Pin-Yi, Young, Fay, Chen, Chun-Yu, Stevens, Brett M., Neering, Sarah J., Rossi, Randall M., Bushnell, Timothy, Kuzin, Igor, Heinrich, David, Bottaro, Andrea, Jordan, Craig T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Chromosome aberrations Cyclin-Dependent Kinase Inhibitor p16 - genetics Cyclin-Dependent Kinase Inhibitor p16 - metabolism Disease Models, Animal Fusion Proteins, bcr-abl - genetics Fusion Proteins, bcr-abl - metabolism Hematologic and hematopoietic diseases Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoid Progenitor Cells - metabolism Lymphoid Progenitor Cells - pathology Medical genetics Medical sciences Mice Mice, Transgenic Neoplasia Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
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