Prediction of Preeclampsia – A Workshop Report
Abstract Understanding the mechanisms of disease responsible for the syndrome of preeclampsia as well as early risk assessment is still a major challenge. The concentrations of circulating proteins in maternal blood such as placental growth factor, soluble vascular endothelial growth factor receptor...
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| Veröffentlicht in: | Placenta (Eastbourne) 2008-03, Vol.29 (Suppl A), p.83-85 |
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| creator | Than, N.G Romero, R Hillermann, R Cozzi, V Nie, G Huppertz, B |
| description | Abstract Understanding the mechanisms of disease responsible for the syndrome of preeclampsia as well as early risk assessment is still a major challenge. The concentrations of circulating proteins in maternal blood such as placental growth factor, soluble vascular endothelial growth factor receptor-1 and soluble endoglin are altered weeks before the onset of clinical symptoms of the syndrome. Recently, other proteins in maternal serum, such as activin A, inhibin A, PAPP-A, and PP13 have been suggested to be of value in first trimester risk assessment. Since preeclampsia is a syndrome, it seems unlikely that a single test will predict all forms of preeclampsia. This realization has led to the formulation of a new conceptual framework suggesting that a combination of markers (biochemical and/or biophysical) may be required to conduct comprehensive risk assessment for the syndrome. |
| doi_str_mv | 10.1016/j.placenta.2007.10.008 |
| format | Article |
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The concentrations of circulating proteins in maternal blood such as placental growth factor, soluble vascular endothelial growth factor receptor-1 and soluble endoglin are altered weeks before the onset of clinical symptoms of the syndrome. Recently, other proteins in maternal serum, such as activin A, inhibin A, PAPP-A, and PP13 have been suggested to be of value in first trimester risk assessment. Since preeclampsia is a syndrome, it seems unlikely that a single test will predict all forms of preeclampsia. 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The concentrations of circulating proteins in maternal blood such as placental growth factor, soluble vascular endothelial growth factor receptor-1 and soluble endoglin are altered weeks before the onset of clinical symptoms of the syndrome. Recently, other proteins in maternal serum, such as activin A, inhibin A, PAPP-A, and PP13 have been suggested to be of value in first trimester risk assessment. Since preeclampsia is a syndrome, it seems unlikely that a single test will predict all forms of preeclampsia. This realization has led to the formulation of a new conceptual framework suggesting that a combination of markers (biochemical and/or biophysical) may be required to conduct comprehensive risk assessment for the syndrome.</description><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Education</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Markers</subject><subject>HtrA3</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>MicroRNA</subject><subject>Obstetrics and Gynecology</subject><subject>PP13</subject><subject>Pre-Eclampsia - diagnosis</subject><subject>Pre-Eclampsia - epidemiology</subject><subject>Pre-Eclampsia - genetics</subject><subject>Prediction</subject><subject>Predictive Value of Tests</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>PTX3</subject><subject>Risk Factors</subject><issn>0143-4004</issn><issn>1532-3102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUttu1DAQtRAVXQq_UOUF3rLM2IntvFRUVblIlVpxEY-W15lQb7NxsLOV-sY_8Id8CY52Wy4vyA-Wx2fOmTkzjB0jLBFQvlovx946Gia75AAqB5cA-hFbYC14KRD4Y7YArERZAVSH7GlKawBoKuRP2CFqkCglLhhcRWq9m3wYitAV-UWut5sxeVv8_P6jOC2-hHiTrsNYfKAxxOkZO-hsn-j5_j5in9-cfzp7V15cvn1_dnpRurquplJ3WHdKcaTW2sa1vHFytWrIWtVysIK05qqifJSu6rZR5DqNSmtaSWydFEfsZMc7blcbaudWo-3NGP3GxjsTrDd__wz-2nwNt4bXGiWqTPByTxDDty2lyWx8ctT3dqCwTUaBaBRUs5LcAV0MKUXqHkQQzGy2WZt7s81s9hzPZufE4z9L_J22dzcDXuwBNjnbd9EOzqcHHAfBa6Fnotc7HGVDbz1Fk5ynweXJRHKTaYP_fy0n_1C43g8-q97QHaV12MYhj8ugSdyA-TivxrwZoAB4rYT4BfmQtsI</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Than, N.G</creator><creator>Romero, R</creator><creator>Hillermann, R</creator><creator>Cozzi, V</creator><creator>Nie, G</creator><creator>Huppertz, B</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080301</creationdate><title>Prediction of Preeclampsia – A Workshop Report</title><author>Than, N.G ; Romero, R ; Hillermann, R ; Cozzi, V ; Nie, G ; Huppertz, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c554t-8f15f7721edaa9cd29c6bb9eaa7d20a3e88274e4e47845d97ecf81788eb61dc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Education</topic><topic>Embryology: invertebrates and vertebrates. 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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Biomarkers Education Embryology: invertebrates and vertebrates. Teratology Female Fundamental and applied biological sciences. Psychology Genetic Markers HtrA3 Humans Internal Medicine MicroRNA Obstetrics and Gynecology PP13 Pre-Eclampsia - diagnosis Pre-Eclampsia - epidemiology Pre-Eclampsia - genetics Prediction Predictive Value of Tests Preeclampsia Pregnancy PTX3 Risk Factors |
| title | Prediction of Preeclampsia – A Workshop Report |
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