NMR and Mutagenesis Evidence for an I Domain Allosteric Site That Regulates Lymphocyte Function-Associated Antigen 1 Ligand Binding

The leukocyte integrin, lymphocyte function-associated antigen 1 (LFA-1) (CD11a/CD18), mediates cell adhesion and signaling in inflammatory and immune responses. To support these functions, LFA-1 must convert from a resting to an activated state that avidly binds its ligands such as intercellular ad...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2000-05, Vol.97 (10), p.5231-5236
Hauptverfasser:	Huth, Jeffrey R., Olejniczak, Edward T., Mendoza, Renaldo, Liang, Heng, Edith A. S. Harris, Lupher, Mark L., Wilson, Amy E., Fesik, Stephen W., Staunton, Donald E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Site Amino Acid Substitution Amino acids Animals Antibodies Binding Sites Biological Sciences CD18 Antigens - chemistry Cell Adhesion Cellular biology Chemical equilibrium COS Cells Crystal structure Crystallography, X-Ray Humans Integrins Intercellular Adhesion Molecule-1 - chemistry Iron deficiency anemia LFA-1 antigen Ligands Lymphocyte Function-Associated Antigen-1 - chemistry Lymphocyte Function-Associated Antigen-1 - genetics Lymphocyte Function-Associated Antigen-1 - physiology Macrophage-1 Antigen - chemistry Models, Molecular Mutagenesis Mutagenesis, Site-Directed NMR Nuclear magnetic resonance Nuclear Magnetic Resonance, Biomolecular - methods Protein Structure, Secondary Recombinant Proteins - chemistry Transfection
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