Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure

The ROCK‐I serine/threonine protein kinase mediates the effects of RhoA to promote the formation of actin stress fibres and integrin‐based focal adhesions. ROCK‐I phosphorylates the unconventional G‐protein RhoE on multiple N‐ and C‐terminal sites. These phosphorylation events stabilise RhoE, which...

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Veröffentlicht in:	The EMBO journal 2008-12, Vol.27 (23), p.3175-3185
Hauptverfasser:	Komander, David, Garg, Ritu, Wan, Paul T C, Ridley, Anne J, Barford, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding sites Catalytic Domain Cercopithecus aethiops COS Cells Crystal structure Crystallography, X-Ray Fibers G proteins HeLa Cells Humans Kinases Models, Biological Models, Molecular Molecular biology Molecular Sequence Data multi-site phosphorylation Mutagenesis, Site-Directed Mutant Proteins - metabolism Mutation Mutation, Missense Phosphorylation Protein Binding Protein Interaction Domains and Motifs Protein Structure, Quaternary rho GTP-Binding Proteins - chemistry rho GTP-Binding Proteins - metabolism rho-Associated Kinases - chemistry rho-Associated Kinases - metabolism RhoE ROCK-I Rocks Sequence Alignment Signal transduction stress fibres
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