Brain SIRT1: Anatomical Distribution and Regulation by Energy Availability

SIRT1 is a nicotinamide adenosine dinucleotide-dependent deacetylase that orchestrates key metabolic adaptations to nutrient deprivation in peripheral tissues. SIRT1 is induced also in the brain by reduced energy intake. However, very little is known about SIRT1 distribution and the biochemical phen...

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Veröffentlicht in:	The Journal of neuroscience 2008-10, Vol.28 (40), p.9989-9996
Hauptverfasser:	Ramadori, Giorgio, Lee, Charlotte E, Bookout, Angie L, Lee, Syann, Williams, Kevin W, Anderson, Jason, Elmquist, Joel K, Coppari, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - anatomy & histology Brain - metabolism Brain - physiology Brain Chemistry - physiology Energy Metabolism - physiology Homeostasis - physiology Humans Male Mice Mice, Inbred C57BL Mice, Obese Mice, Transgenic Sirtuin 1 Sirtuins - metabolism Sirtuins - physiology
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