Sumoylation of LAP1 is involved in the HDAC4-mediated repression of COX-2 transcription

CEBPB, one of the CEBP family members, is a crucial regulator of gene expression during innate immunity, inflammatory responses and adipogenesis. In this study, the EGF-induced increase of CEBPB mRNA is shown to be coincident with the decrease of COX-2 mRNA. We identified that all of the individual...

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Veröffentlicht in:	Nucleic acids research 2008-11, Vol.36 (19), p.6066-6079
Hauptverfasser:	Wang, Wen-Ling, Lee, Yi-Chao, Yang, Wen-Ming, Chang, Wen-Chang, Wang, Ju-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites CCAAT-Enhancer-Binding Protein-beta - biosynthesis CCAAT-Enhancer-Binding Protein-beta - genetics CCAAT-Enhancer-Binding Protein-beta - metabolism Cell Line, Tumor Cyclooxygenase 2 - biosynthesis Cyclooxygenase 2 - genetics Epidermal Growth Factor - pharmacology Gene Regulation, Chromatin and Epigenetics Gene Silencing Histone Deacetylases - metabolism Humans Mutation Promoter Regions, Genetic Protein Isoforms - metabolism Repressor Proteins - biosynthesis Repressor Proteins - genetics Repressor Proteins - metabolism Response Elements Small Ubiquitin-Related Modifier Proteins - metabolism Transcription, Genetic
Online-Zugang:	Volltext
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