Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer
Apoptosis is important for targeting cancer cells for destruction. Various single-nucleotide polymorphisms (SNPs) in apoptotic genes have been associated with increased risks in lung cancer, particularly FAS −1377 G>A (rs2234767), FASLG −844 C>T (rs763110), IL1B +3954 C>T Phe105Phe (rs11436...
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| Veröffentlicht in: | Carcinogenesis (New York) 2008-11, Vol.29 (11), p.2147-2152 |
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| creator | Ter-Minassian, Monica Zhai, Rihong Asomaning, Kofi Su, Li Zhou, Wei Liu, Geoffrey Heist, Rebecca Suk Lynch, Thomas J. Wain, John C. Lin, Xihong DeVivo, Immaculata Christiani, David C. |
| description | Apoptosis is important for targeting cancer cells for destruction. Various single-nucleotide polymorphisms (SNPs) in apoptotic genes have been associated with increased risks in lung cancer, particularly FAS −1377 G>A (rs2234767), FASLG −844 C>T (rs763110), IL1B +3954 C>T Phe105Phe (rs1143634) and BAT3 Ser625Pro (rs1052486). We studied the association of these SNPs with non-small cell lung cancer (NSCLC) in a large case–control study (N = 4263: 2644 cases and 1619 controls). No associations with NSCLC were observed in the main effects analysis for all four SNPs, adjusting for age, gender, smoking status, pack-years and years since smoking cessation. In subjects under age 60, for FASLG −844 C>T polymorphism, CT compared with the CC genotype, was significantly associated with increased risk of NSCLC, adjusted odds ratio (aOR) = 1.58 (1.22, 2.05), P = 0.0006 and TT aOR = 1.45 (1.01, 2.04), P = 0.04. In contrast, for those over age 60, the CT aOR = 0.91 (0.73, 1.13), P = 0.37 and TT aOR = 0.86 (0.64, 1.16), P = 0.32. The P-value for the age–genotype interaction was 0.004. For the IL1B +3954 C>T polymorphism, compared with the CC genotype, TT showed significant associations in former smokers and in men but tests of interaction were not significant (Psmoking = 0.24, Pgender = 0.17). No interactions were observed for FAS −1377 G>A and BAT3 Ser625Pro polymorphisms. Our findings indicate that age and smoking may modify the association of the FASLG −844 and IL1B + 3954 SNPs with the risk of NSCLC. |
| doi_str_mv | 10.1093/carcin/bgn205 |
| format | Article |
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Various single-nucleotide polymorphisms (SNPs) in apoptotic genes have been associated with increased risks in lung cancer, particularly FAS −1377 G>A (rs2234767), FASLG −844 C>T (rs763110), IL1B +3954 C>T Phe105Phe (rs1143634) and BAT3 Ser625Pro (rs1052486). We studied the association of these SNPs with non-small cell lung cancer (NSCLC) in a large case–control study (N = 4263: 2644 cases and 1619 controls). No associations with NSCLC were observed in the main effects analysis for all four SNPs, adjusting for age, gender, smoking status, pack-years and years since smoking cessation. In subjects under age 60, for FASLG −844 C>T polymorphism, CT compared with the CC genotype, was significantly associated with increased risk of NSCLC, adjusted odds ratio (aOR) = 1.58 (1.22, 2.05), P = 0.0006 and TT aOR = 1.45 (1.01, 2.04), P = 0.04. In contrast, for those over age 60, the CT aOR = 0.91 (0.73, 1.13), P = 0.37 and TT aOR = 0.86 (0.64, 1.16), P = 0.32. The P-value for the age–genotype interaction was 0.004. For the IL1B +3954 C>T polymorphism, compared with the CC genotype, TT showed significant associations in former smokers and in men but tests of interaction were not significant (Psmoking = 0.24, Pgender = 0.17). No interactions were observed for FAS −1377 G>A and BAT3 Ser625Pro polymorphisms. Our findings indicate that age and smoking may modify the association of the FASLG −844 and IL1B + 3954 SNPs with the risk of NSCLC.</description><identifier>ISSN: 0143-3334</identifier><identifier>EISSN: 1460-2180</identifier><identifier>DOI: 10.1093/carcin/bgn205</identifier><identifier>PMID: 18757527</identifier><identifier>CODEN: CRNGDP</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Apoptosis - genetics ; Biological and medical sciences ; Carcinogenesis, carcinogens and anticarcinogens ; Carcinoma, Non-Small-Cell Lung - genetics ; Case-Control Studies ; Fas Ligand Protein - genetics ; fas Receptor - genetics ; Humans ; Interleukin-1beta - genetics ; Lung cancer ; Lung Neoplasms - genetics ; Medical sciences ; Middle Aged ; Molecular Epidemiology ; Pneumology ; Polymorphism, Single Nucleotide ; Smoking ; Tobacco, tobacco smoking ; Toxicology ; Tumors ; Tumors of the respiratory system and mediastinum</subject><ispartof>Carcinogenesis (New York), 2008-11, Vol.29 (11), p.2147-2152</ispartof><rights>Published by Oxford University Press 2008. 2008</rights><rights>2009 INIST-CNRS</rights><rights>Published by Oxford University Press 2008.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c610t-4da979a4a1d41ee18fa1e8a836de22fd5feee369b16c8b6c2b2f1fa56df7d2213</citedby><cites>FETCH-LOGICAL-c610t-4da979a4a1d41ee18fa1e8a836de22fd5feee369b16c8b6c2b2f1fa56df7d2213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20830764$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18757527$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ter-Minassian, Monica</creatorcontrib><creatorcontrib>Zhai, Rihong</creatorcontrib><creatorcontrib>Asomaning, Kofi</creatorcontrib><creatorcontrib>Su, Li</creatorcontrib><creatorcontrib>Zhou, Wei</creatorcontrib><creatorcontrib>Liu, Geoffrey</creatorcontrib><creatorcontrib>Heist, Rebecca Suk</creatorcontrib><creatorcontrib>Lynch, Thomas J.</creatorcontrib><creatorcontrib>Wain, John C.</creatorcontrib><creatorcontrib>Lin, Xihong</creatorcontrib><creatorcontrib>DeVivo, Immaculata</creatorcontrib><creatorcontrib>Christiani, David C.</creatorcontrib><title>Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer</title><title>Carcinogenesis (New York)</title><addtitle>Carcinogenesis</addtitle><description>Apoptosis is important for targeting cancer cells for destruction. Various single-nucleotide polymorphisms (SNPs) in apoptotic genes have been associated with increased risks in lung cancer, particularly FAS −1377 G>A (rs2234767), FASLG −844 C>T (rs763110), IL1B +3954 C>T Phe105Phe (rs1143634) and BAT3 Ser625Pro (rs1052486). We studied the association of these SNPs with non-small cell lung cancer (NSCLC) in a large case–control study (N = 4263: 2644 cases and 1619 controls). No associations with NSCLC were observed in the main effects analysis for all four SNPs, adjusting for age, gender, smoking status, pack-years and years since smoking cessation. In subjects under age 60, for FASLG −844 C>T polymorphism, CT compared with the CC genotype, was significantly associated with increased risk of NSCLC, adjusted odds ratio (aOR) = 1.58 (1.22, 2.05), P = 0.0006 and TT aOR = 1.45 (1.01, 2.04), P = 0.04. In contrast, for those over age 60, the CT aOR = 0.91 (0.73, 1.13), P = 0.37 and TT aOR = 0.86 (0.64, 1.16), P = 0.32. The P-value for the age–genotype interaction was 0.004. For the IL1B +3954 C>T polymorphism, compared with the CC genotype, TT showed significant associations in former smokers and in men but tests of interaction were not significant (Psmoking = 0.24, Pgender = 0.17). No interactions were observed for FAS −1377 G>A and BAT3 Ser625Pro polymorphisms. Our findings indicate that age and smoking may modify the association of the FASLG −844 and IL1B + 3954 SNPs with the risk of NSCLC.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Apoptosis - genetics</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Carcinoma, Non-Small-Cell Lung - genetics</subject><subject>Case-Control Studies</subject><subject>Fas Ligand Protein - genetics</subject><subject>fas Receptor - genetics</subject><subject>Humans</subject><subject>Interleukin-1beta - genetics</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - genetics</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Epidemiology</subject><subject>Pneumology</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Smoking</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><subject>Tumors</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0143-3334</issn><issn>1460-2180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c-L1DAUB_AgijuuHr1KEBQPWzcvaZP2IiyD4wqLXlwQLyFNk0522qQmrbj_vR1axh8XL8khH77vvTyEngN5C6Ril1pF7fxl3XpKigdoAzknGYWSPEQbAjnLGGP5GXqS0h0hwFlRPUZnUIpCFFRs0O3VEIYxJJdwa7zBQ-ju-xCHvUt9usCqNRc49eHgfIuVb_C4Nzi6dMDBYh98lnrVdVib-eim2WjltYlP0SOrumSerfc5ut29_7K9zm4-f_i4vbrJNAcyZnmjKlGpXEGTgzFQWgWmVCXjjaHUNoU1xjBe1cB1WXNNa2rBqoI3VjSUAjtH75bcYap702jjx6g6OUTXq3gvg3Ly7xfv9rINPyQthABWzgGv14AYvk8mjbJ36TiN8iZMSUKVQ8VLMsOX_8C7MEU_DycpVCxnlBzTsgXpGFKKxp46ASKP25LLtuSyrdm_-LP933pdzwxerUAlrTob59916eSONYng-ezeLC5Mw39rrj26NJqfJ6ziQXLBRCGvv36Tu3JXwZZ8kgX7BRozvYU</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>Ter-Minassian, Monica</creator><creator>Zhai, Rihong</creator><creator>Asomaning, Kofi</creator><creator>Su, Li</creator><creator>Zhou, Wei</creator><creator>Liu, Geoffrey</creator><creator>Heist, Rebecca Suk</creator><creator>Lynch, Thomas J.</creator><creator>Wain, John C.</creator><creator>Lin, Xihong</creator><creator>DeVivo, Immaculata</creator><creator>Christiani, David C.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20081101</creationdate><title>Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer</title><author>Ter-Minassian, Monica ; Zhai, Rihong ; Asomaning, Kofi ; Su, Li ; Zhou, Wei ; Liu, Geoffrey ; Heist, Rebecca Suk ; Lynch, Thomas J. ; Wain, John C. ; Lin, Xihong ; DeVivo, Immaculata ; Christiani, David C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c610t-4da979a4a1d41ee18fa1e8a836de22fd5feee369b16c8b6c2b2f1fa56df7d2213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Apoptosis - genetics</topic><topic>Biological and medical sciences</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Carcinoma, Non-Small-Cell Lung - genetics</topic><topic>Case-Control Studies</topic><topic>Fas Ligand Protein - genetics</topic><topic>fas Receptor - genetics</topic><topic>Humans</topic><topic>Interleukin-1beta - genetics</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - genetics</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular Epidemiology</topic><topic>Pneumology</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Smoking</topic><topic>Tobacco, tobacco smoking</topic><topic>Toxicology</topic><topic>Tumors</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ter-Minassian, Monica</creatorcontrib><creatorcontrib>Zhai, Rihong</creatorcontrib><creatorcontrib>Asomaning, Kofi</creatorcontrib><creatorcontrib>Su, Li</creatorcontrib><creatorcontrib>Zhou, Wei</creatorcontrib><creatorcontrib>Liu, Geoffrey</creatorcontrib><creatorcontrib>Heist, Rebecca Suk</creatorcontrib><creatorcontrib>Lynch, Thomas J.</creatorcontrib><creatorcontrib>Wain, John C.</creatorcontrib><creatorcontrib>Lin, Xihong</creatorcontrib><creatorcontrib>DeVivo, Immaculata</creatorcontrib><creatorcontrib>Christiani, David C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Carcinogenesis (New York)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ter-Minassian, Monica</au><au>Zhai, Rihong</au><au>Asomaning, Kofi</au><au>Su, Li</au><au>Zhou, Wei</au><au>Liu, Geoffrey</au><au>Heist, Rebecca Suk</au><au>Lynch, Thomas J.</au><au>Wain, John C.</au><au>Lin, Xihong</au><au>DeVivo, Immaculata</au><au>Christiani, David C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer</atitle><jtitle>Carcinogenesis (New York)</jtitle><addtitle>Carcinogenesis</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>29</volume><issue>11</issue><spage>2147</spage><epage>2152</epage><pages>2147-2152</pages><issn>0143-3334</issn><eissn>1460-2180</eissn><coden>CRNGDP</coden><abstract>Apoptosis is important for targeting cancer cells for destruction. Various single-nucleotide polymorphisms (SNPs) in apoptotic genes have been associated with increased risks in lung cancer, particularly FAS −1377 G>A (rs2234767), FASLG −844 C>T (rs763110), IL1B +3954 C>T Phe105Phe (rs1143634) and BAT3 Ser625Pro (rs1052486). We studied the association of these SNPs with non-small cell lung cancer (NSCLC) in a large case–control study (N = 4263: 2644 cases and 1619 controls). No associations with NSCLC were observed in the main effects analysis for all four SNPs, adjusting for age, gender, smoking status, pack-years and years since smoking cessation. In subjects under age 60, for FASLG −844 C>T polymorphism, CT compared with the CC genotype, was significantly associated with increased risk of NSCLC, adjusted odds ratio (aOR) = 1.58 (1.22, 2.05), P = 0.0006 and TT aOR = 1.45 (1.01, 2.04), P = 0.04. In contrast, for those over age 60, the CT aOR = 0.91 (0.73, 1.13), P = 0.37 and TT aOR = 0.86 (0.64, 1.16), P = 0.32. The P-value for the age–genotype interaction was 0.004. For the IL1B +3954 C>T polymorphism, compared with the CC genotype, TT showed significant associations in former smokers and in men but tests of interaction were not significant (Psmoking = 0.24, Pgender = 0.17). No interactions were observed for FAS −1377 G>A and BAT3 Ser625Pro polymorphisms. Our findings indicate that age and smoking may modify the association of the FASLG −844 and IL1B + 3954 SNPs with the risk of NSCLC.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>18757527</pmid><doi>10.1093/carcin/bgn205</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Factors Aged Aged, 80 and over Apoptosis - genetics Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinoma, Non-Small-Cell Lung - genetics Case-Control Studies Fas Ligand Protein - genetics fas Receptor - genetics Humans Interleukin-1beta - genetics Lung cancer Lung Neoplasms - genetics Medical sciences Middle Aged Molecular Epidemiology Pneumology Polymorphism, Single Nucleotide Smoking Tobacco, tobacco smoking Toxicology Tumors Tumors of the respiratory system and mediastinum |
| title | Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer |
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