Structural Insights into the Role of Mutations in Amyloidogenesis

Mechanisms of amyloidogenesis are not well understood, including potential structural contributions of mutations in the process. Our previous research indicated that the dimer interface of amyloidogenic immunoglobulin light chain protein AL-09 is twisted 90° relative to the protein from its germline...

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Veröffentlicht in:	The Journal of biological chemistry 2008-11, Vol.283 (45), p.30950-30956
Hauptverfasser:	Baden, Elizabeth M., Randles, Edward G., Aboagye, Awo K., Thompson, James R., Ramirez-Alvarado, Marina
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Amyloid - chemistry Amyloid - genetics Amyloid - metabolism Amyloidosis - genetics Amyloidosis - metabolism BASIC BIOLOGICAL SCIENCES Dimerization DIMERS Germ-Line Mutation Humans Immunoglobulin kappa-Chains - chemistry Immunoglobulin kappa-Chains - genetics Immunoglobulin kappa-Chains - metabolism IMMUNOGLOBULINS MUTANTS MUTATIONS Protein Structure and Folding PROTEINS SOMATIC MUTATIONS STABILITY THERMODYNAMICS
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