S10 phosphorylation of p27 mediates atRA induced growth arrest in ovarian carcinoma cell lines

All trans retinoic acid (atRA) has been shown to inhibit the growth of CAOV3 ovarian carcinoma cells and to elevate the level of p27 cyclin‐dependent kinase inhibitor. We report here that phosphorylation at S10 residue is an important event in mediating p27 role in atRA induced growth arrest. atRA t...

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Veröffentlicht in:	Journal of cellular physiology 2008-11, Vol.217 (2), p.558-568
Hauptverfasser:	Radu, Maria, Soprano, Dianne R., Soprano, Kenneth J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Cell Line, Tumor Cell Nucleus - metabolism Cell Proliferation - drug effects Cyclin-Dependent Kinase Inhibitor p27 Cyclin-Dependent Kinases - metabolism Cyclins - metabolism Cytoplasm - metabolism Drug Resistance, Neoplasm Female Gene Expression Regulation, Neoplastic - drug effects Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Mutation Ovarian Neoplasms - enzymology Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Phosphorylation Proteasome Endopeptidase Complex - metabolism Protein Binding S Phase - drug effects S Phase - genetics S-Phase Kinase-Associated Proteins - metabolism Serine Time Factors Transfection Tretinoin - pharmacology Up-Regulation
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