TIM-1 and TIM-3 proteins in immune regulation

Over the last several years, there has been increasing interest in the role of proteins of the TIM (T cell immunoglobulin and mucin domain) family in regulating immune responses. Despite what the name suggests, proteins of this family function in a much more widespread manner than just on T cells, a...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2008-10, Vol.44 (1), p.9-13
Hauptverfasser:	Su, Ee Wern, Lin, Jean Y., Kane, Lawrence P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Apoptosis Graft Rejection - physiopathology Graft Rejection - prevention & control Hepatitis A Virus Cellular Receptor 1 Hepatitis A Virus Cellular Receptor 2 Humans Immunity - physiology Lymphocyte Activation - physiology Macrophages Macrophages - physiology Mast Cells - physiology Membrane Glycoproteins - physiology Membrane Proteins - physiology Mice Receptors, Cell Surface - physiology Receptors, Virus - physiology T cells T-Lymphocytes - immunology T-Lymphocytes, Regulatory - physiology Tolerance
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Beschreibung
Zusammenfassung:	Over the last several years, there has been increasing interest in the role of proteins of the TIM (T cell immunoglobulin and mucin domain) family in regulating immune responses. Despite what the name suggests, proteins of this family function in a much more widespread manner than just on T cells, as we will discuss in this review. We therefore propose that the definition of TIM be adjusted to “ transmembrane immunoglobulin and mucin”.
ISSN:	1043-4666 1096-0023
DOI:	10.1016/j.cyto.2008.06.013