Panton-Valentine Leukocidin Is Not a Virulence Determinant in Murine Models of Community-Associated Methicillin-Resistant Staphylococcus aureus Disease

Increases in the incidence and severity of community-associated methicillin-resistant Staphylococcus aureus (CAMRSA) infections have spawned efforts to define unique virulence properties among prevalent strains. Panton-Valentine leukocidin (PVL), a pore-forming cytotoxin, has garnered attention beca...

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Veröffentlicht in:	The Journal of infectious diseases 2008-10, Vol.198 (8), p.1166-1170
Hauptverfasser:	Bubeck Wardenburg, Juliane, Palazzolo-Ballance, Amy M., Otto, Michael, Schneewind, Olaf, DeLeo, Frank R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abscesses Animals Bacteria Bacterial Toxins - genetics Bacterial Toxins - metabolism Community-Acquired Infections - microbiology Community-Acquired Infections - pathology Disease models Disease Models, Animal Epidemiology Exotoxins - genetics Exotoxins - metabolism Female Humans Infections Leukocidins Leukocidins - genetics Leukocidins - metabolism Methicillin Resistance Mice Mice, Inbred BALB C Mutation Pathogenesis Pneumonia, Staphylococcal - microbiology Pneumonia, Staphylococcal - mortality Pneumonia, Staphylococcal - pathology Staphylococcal pneumonia Staphylococcal Skin Infections - microbiology Staphylococcal Skin Infections - pathology Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - genetics Staphylococcus aureus - isolation & purification Staphylococcus aureus - pathogenicity Virulence
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