Gamma-vinyl GABA inhibits cocaine-triggered reinstatement of drug-seeking behavior in rats by a non-dopaminergic mechanism

Abstract Relapse to drug use is a core feature of addiction. Previous studies demonstrate that γ-vinyl GABA (GVG), an irreversible GABA transaminase inhibitor, attenuates the acute rewarding effects of cocaine and other addictive drugs. We here report that systemic administration of GVG (25–300 mg/k...

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Veröffentlicht in:	Drug and alcohol dependence 2008-10, Vol.97 (3), p.216-225
Hauptverfasser:	Peng, Xiao-Qing, Li, Xia, Gilbert, Jeremy G, Pak, Arlene C, Ashby, Charles R, Brodie, Jonathan D, Dewey, Stephen L, Gardner, Eliot L, Xi, Zheng-Xiong
Format:	Artikel
Sprache:	eng
Schlagworte:	Addictive behaviors Adult and adolescent clinical studies Animals Behavior, Addictive - prevention & control Behavior, Animal - drug effects Biological and medical sciences Chromatography, High Pressure Liquid Cocaine Cocaine - administration & dosage Dopamine Dopamine - metabolism Drug addiction Exploratory Behavior - drug effects Extinction, Psychological - drug effects GABA GABA Agents - administration & dosage GABA Agents - pharmacology Gamma-vinyl GABA Male Medical sciences Neuropharmacology Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Pharmacology. Drug treatments Psychiatry Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Rats Rats, Long-Evans Reinstatement Relapse Reward Self Administration Vigabatrin - administration & dosage Vigabatrin - pharmacology
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