Opposing actions of Notch1 and VEGF in post-natal cardiac valve endothelial cells

The endothelium of the cardiac valves is unique compared the rest of the vasculature in its ability to undergo an endothelial-to-mesenchymal transformation (EMT) in vitro in response to transforming growth factor-β (TGF-β). EMT is a critical event during embryonic valve development, and both VEGF-A...

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Veröffentlicht in:	Biochemical and biophysical research communications 2008-09, Vol.374 (3), p.512-516
Hauptverfasser:	Yang, Jeong-Hee, Wylie-Sears, Jill, Bischoff, Joyce
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aortic Valve - cytology Aortic Valve - drug effects Aortic Valve - growth & development Cell Differentiation - drug effects Cell Proliferation - drug effects Dipeptides - pharmacology Endothelial-to-mesenchymal transformation Endothelium, Vascular - cytology Endothelium, Vascular - growth & development Endothelium, Vascular - metabolism Humans Mesoderm - cytology Mesoderm - drug effects Mesoderm - growth & development Notch1 Receptor, Notch1 - physiology Sheep TGF-β Transforming Growth Factor beta1 - antagonists & inhibitors Transforming Growth Factor beta1 - pharmacology Valve endothelial cells Vascular Endothelial Growth Factor A - pharmacology Vascular Endothelial Growth Factor A - physiology Vascular Endothelial Growth Factor Receptor-2 - physiology VEGF-A
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