A conjugated synthetic peptide corresponding to the C-terminal region of Clostridium perfringens type A enterotoxin elicits an enterotoxin-neutralizing antibody response in mice

A synthetic peptide homolog corresponding to the C-terminal 30 amino acids of Clostridium perfringens type A enterotoxin (CPE) was conjugated to a thyroglobulin carrier and used to immunize mice. Conjugate-immunized mice produced antibodies which neutralized native CPE cytotoxicity, at least in part...

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Veröffentlicht in:	Infection and Immunity 1992-09, Vol.60 (9), p.3947-3951
Hauptverfasser:	Mietzner, T.A. (University of Pittsburgh School of Medicine, Pittsburgh, PA), Kokai-Kun, J.F, Hanna, P.C, McClane, B.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Bacterial - analysis Bacteriology Biological and medical sciences CLOSTRIDIUM PERFRINGENS Clostridium perfringens - immunology ENTEROTOXINAS ENTEROTOXINE Enterotoxins - immunology Female Fundamental and applied biological sciences. Psychology IMMUNISATION Immunization INMUNIZACION Mice Mice, Inbred BALB C Microbiology Molecular Sequence Data NEUTRALISATION NEUTRALIZACION PEPTIDE Peptide Fragments - immunology PEPTIDOS RATON REPONSE IMMUNITAIRE RESPUESTA INMUNOLOGICA SOURIS Thyroglobulin - administration & dosage Thyroglobulin - immunology TOXICIDAD POR INGESTION TOXICITE PAR INGESTION VACCIN Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Synthetic - immunology VACUNA
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