Inhibition of SNAT2 by Metabolic Acidosis Enhances Proteolysis in Skeletal Muscle

Insulin resistance is a major cause of muscle wasting in patients with ESRD. Uremic metabolic acidosis impairs insulin signaling, which normally suppresses proteolysis. The low pH may inhibit the SNAT2 l-Glutamine (L-Gln) transporter, which controls protein synthesis via amino acid-dependent insulin...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2008-11, Vol.19 (11), p.2119-2129
Hauptverfasser:	EVANS, Kate, NASIM, Zeerak, BROWN, Jeremy, CLAPP, Emma, AMIN, Amin, BIN YANG, HERBERT, Terence P, BEVINGTON, Alan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis - metabolism Amino Acid Transport System A - antagonists & inhibitors Amino Acid Transport System A - genetics Amino Acid Transport System A - metabolism Animals Base Sequence Basic Research Biological and medical sciences Carrier Proteins - metabolism Cell Line Glutamine - metabolism Humans Hydrogen-Ion Concentration Insulin Resistance Medical sciences Muscle, Skeletal - metabolism Myoblasts, Skeletal - metabolism Nephrology. Urinary tract diseases Peptide Hydrolases - metabolism Phosphatidylinositol 3-Kinases - metabolism Phosphotransferases (Alcohol Group Acceptor) - metabolism Proto-Oncogene Proteins c-akt - metabolism Rats RNA, Small Interfering - genetics Signal Transduction TOR Serine-Threonine Kinases
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