Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection

Hematopoietic stem and progenitor cells were previously found to express Toll-like receptors (TLRs), suggesting that bacterial/viral products may influence blood cell formation. We now show that common lymphoid progenitors (CLPs) from mice with active HSV-1 infection are biased to dendritic cell (DC...

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Veröffentlicht in:	Blood 2008-11, Vol.112 (9), p.3753-3761
Hauptverfasser:	Welner, Robert S., Pelayo, Rosana, Nagai, Yoshinori, Garrett, Karla P., Wuest, Todd R., Carr, Daniel J., Borghesi, Lisa A., Farrar, Michael A., Kincade, Paul W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - immunology B-Lymphocytes - pathology Cell Differentiation CpG Islands - immunology Dendritic Cells - immunology Dendritic Cells - pathology Hematopoietic Stem Cells - immunology Hematopoietic Stem Cells - pathology Herpes Simplex - immunology Herpes Simplex - pathology Herpesvirus 1, Human Immunobiology In Vitro Techniques Ligands Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic STAT5 Transcription Factor - metabolism Toll-Like Receptor 9 - deficiency Toll-Like Receptor 9 - genetics Toll-Like Receptor 9 - metabolism Tumor Necrosis Factor-alpha - deficiency Tumor Necrosis Factor-alpha - genetics
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