Temporary angiotensin II blockade at the prediabetic stage attenuates the development of renal injury in type 2 diabetic rats

Whether temporary angiotensin II (AngII) blockade at the prediabetic stage attenuates renal injury in type 2 diabetic OLETF rats later in life was investigated. OLETF rats were treated with an AT(1) receptor antagonist (olmesartan, 0.01% in food), angiotensin-converting enzyme inhibitor (temocapril,...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2005-03, Vol.16 (3), p.703-711
Hauptverfasser:	NAGAI, Yukiko, LI YAO, KOHNO, Masakazu, ABE, Youichi, NISHIYAMA, Akira, KOBORI, Hiroyuki, MIYATA, Kayoko, OZAWA, Yuri, MIYATAKE, Akira, YUKIMURA, Tokihito, SHOKOJI, Takatomi, KIMURA, Shoji, KIYOMOTO, Hideyasu
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - genetics Angiotensin II Type 1 Receptor Blockers - pharmacology Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Antihypertensive Agents - pharmacology Biological and medical sciences Blood Glucose Blood Pressure Body Weight Collagen - metabolism Connective Tissue Growth Factor Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - prevention & control Diabetic Nephropathies - drug therapy Diabetic Nephropathies - prevention & control Drug Therapy, Combination Hydralazine - pharmacology Imidazoles - pharmacology Immediate-Early Proteins - metabolism Intercellular Signaling Peptides and Proteins - metabolism Male Medical sciences NADPH Oxidases - metabolism Nephrology. Urinary tract diseases Olmesartan Medoxomil Pharmacology. Drug treatments Prediabetic State - drug therapy Rats Rats, Inbred OLETF Receptors, Angiotensin - genetics Renin - genetics Tetrazoles - pharmacology Thiazepines - pharmacology Thiobarbituric Acid Reactive Substances - metabolism Transforming Growth Factor beta - metabolism Urinary system
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