TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events

Ligands from dying cells are a source of Toll-like receptor (TLR) activating agents. Although TLR3 is known to respond to RNA from necrotic cells, the relative importance of this response in vivo during acute inflammatory processes has not been fully explored. We observed the involvement of TLR3 act...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of experimental medicine 2008-10, Vol.205 (11), p.2609-2621
Hauptverfasser:	Cavassani, Karen A, Ishii, Makoto, Wen, Haitao, Schaller, Matthew A, Lincoln, Pamela M, Lukacs, Nicholas W, Hogaboam, Cory M, Kunkel, Steven L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Flow Cytometry Intestine, Large - immunology Intestine, Large - metabolism Ischemia - immunology Ischemia - metabolism Mice Mice, Knockout Necrosis - metabolism Neutrophils - metabolism RNA - metabolism Sepsis - immunology Sepsis - metabolism Toll-Like Receptor 3 - genetics Toll-Like Receptor 3 - metabolism Up-Regulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!