Gradual phenotypic conversion associated with immortalization of cultured human mammary epithelial cells

Examination of the process of immortal transformation in early passages of two human mammary epithelial cell (HMEC) lines suggests the involvement of an epigenetic step. These lines, 184A1 and 184B5, arose after in vitro exposure of finite lifespan 184 HMEC to a chemical carcinogen, and both are clo...

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Veröffentlicht in:	Molecular biology of the cell 1997-12, Vol.8 (12), p.2391-2405
Hauptverfasser:	Stampfer, M R, Bodnar, A, Garbe, J, Wong, M, Pan, A, Villeponteau, B, Yaswen, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Breast - cytology Breast - drug effects Breast - enzymology Breast - metabolism Carcinogens - pharmacology Cell Division - drug effects Cell Line, Transformed Cell Size - drug effects Cells, Cultured Cellular Senescence - drug effects Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - enzymology Epithelial Cells - metabolism Female Humans Phenotype Telomerase - metabolism Telomere - genetics Telomere - metabolism Time Factors Transforming Growth Factor beta - pharmacology
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