Two Single Nucleotide Polymorphisms Identify the Highest-Risk Diabetes HLA Genotype : Potential for Rapid Screening

People with the HLA genotype DRB1*0301-DQA1*0501-DQB1*0201/DRB1*04-DQA1*0301-DQB1*0302 (DR3/4-DQ8) are at the highest risk of developing type 1 diabetes. We sought to find an inexpensive, rapid test to identify DR3/4-DQ8 subjects using two single nucleotide polymorphisms (SNPs). SNPs rs2040410 and r...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2008-11, Vol.57 (11), p.3152-3155
Hauptverfasser:	BARKER, Jennifer M, TRIOLO, Taylor M, ALY, Theresa A, BASCHAL, Erin E, BABU, Sunanda R, KRETOWSKI, Adam, REWERS, Marian J, EISENBARTH, George S
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Consortia Development and progression Diabetes Diabetes Mellitus, Type 1 - diagnosis Diabetes Mellitus, Type 1 - genetics Diabetes. Impaired glucose tolerance Diagnosis Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzymes Etiopathogenesis. Screening. Investigations. Target tissue resistance Gene Frequency Genetic aspects Genetics Genotype Genotype & phenotype Genotypes HLA-D Antigens - genetics HLA-DQ Antigens - genetics HLA-DR Antigens - genetics Humans Hybridization Medical sciences Physiological aspects Polymorphism, Single Nucleotide Prevention Research design Review boards Risk Factors Siblings Type 1 diabetes
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