Adenoviral Overexpression and Small Interfering RNA Suppression Demonstrate That Plasminogen Activator Inhibitor-1 Produces Elevated Collagen Accumulation in Normal and Keloid Fibroblasts

Keloids are tumor-like skin scars that grow as a result of the aberrant healing of skin injuries, with no effective treatment. We provide new evidence that both overexpression of plasminogen activator inhibitor-1 (PAI-1) and elevated collagen accumulation are intrinsic features of keloid fibroblasts...

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Veröffentlicht in:	The American journal of pathology 2008-11, Vol.173 (5), p.1311-1325
Hauptverfasser:	Tuan, Tai-Lan, Hwu, Paul, Ho, Wendy, Yiu, Peter, Chang, Richard, Wysocki, Annette, Benya, Paul D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus Adolescent Adult Aged Biological and medical sciences Cells, Cultured Collagen - biosynthesis Collagen - metabolism Dermatology Female Fibroblasts - metabolism Fibroblasts - pathology Fibroblasts - virology Humans Investigative techniques, diagnostic techniques (general aspects) Keloid - metabolism Keloid - pathology Male Medical sciences Middle Aged Mutation - genetics Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Plasminogen Activator Inhibitor 1 - metabolism Regular RNA, Small Interfering - metabolism Skin involvement in other diseases. Miscellaneous. General aspects Suppression, Genetic Transduction, Genetic
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