Molecular mechanisms of inherited demyelinating neuropathies

The past 15 years have witnessed the identification of more than 25 genes responsible for inherited neuropathies in humans, many associated with primary alterations of the myelin sheath. A remarkable body of work in patients, as well as animal and cellular models, has defined the clinical and molecu...

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Veröffentlicht in:	Glia 2008-11, Vol.56 (14), p.1578-1589
Hauptverfasser:	Scherer, Steven S., Wrabetz, Lawrence
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Demyelinating Diseases - genetics Gene Expression Regulation Genetic Predisposition to Disease Hereditary Sensory and Motor Neuropathy - genetics Humans Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use mutation myelin Myelin Proteins - genetics Myelin Proteins - immunology Myelin Proteins - metabolism Myelin Sheath - genetics Myelin Sheath - immunology Myelin Sheath - pathology Peripheral Nerves - immunology Peripheral Nerves - pathology Peripheral Nerves - physiopathology Polyradiculoneuropathy - genetics Polyradiculoneuropathy - immunology Polyradiculoneuropathy - physiopathology Schwann cell Schwann Cells - immunology Schwann Cells - metabolism Schwann Cells - pathology signal transduction transcription
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