HVEM and Nectin-1 Are the Major Mediators of Herpes Simplex Virus 1 (HSV-1) Entry into Human Conjunctival Epithelium

The human conjunctiva is a natural target for herpes simplex virus (HSV)-1 infection. The goals of this study were to investigate the cellular and molecular mechanisms of HSV-1 entry into human conjunctival epithelial (HCjE) cells. Specific features of entry studied included the method of initial vi...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2008-09, Vol.49 (9), p.4026-4035
Hauptverfasser:	Akhtar, Jihan, Tiwari, Vaibhav, Oh, Myung-Jin, Kovacs, Maria, Jani, Aarti, Kovacs, S. Krisztian, Valyi-Nagy, Tibor, Shukla, Deepak
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences CHO Cells Conjunctiva - physiology Conjunctiva - virology Cricetinae Cricetulus Epithelial Cells - physiology Epithelial Cells - virology Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Herpes Simplex - prevention & control Herpesvirus 1, Human - pathogenicity Herpesvirus 1, Human - physiology Humans Intermediate Filament Proteins - physiology Medical sciences Nerve Tissue Proteins - physiology Nestin Ophthalmology Pseudopodia - virology Receptors, Tumor Necrosis Factor, Member 14 - physiology Vertebrates: nervous system and sense organs Viral Plaque Assay Virus Internalization
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