The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement

A novel dendritic cell (DC)–restricted molecule, Clec9A, was identified by gene expression profiling of mouse DC subtypes. Based on sequence similarity, a human ortholog was identified. Clec9A encodes a type II membrane protein with a single extracellular C-type lectin domain. Both the mouse Clec9A...

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Veröffentlicht in:	Blood 2008-10, Vol.112 (8), p.3264-3273
Hauptverfasser:	Caminschi, Irina, Proietto, Anna I., Ahmet, Fatma, Kitsoulis, Susie, Shin Teh, Joo, Lo, Jennifer C.Y., Rizzitelli, Alexandra, Wu, Li, Vremec, David, van Dommelen, Serani L.H., Campbell, Ian K., Maraskovsky, Eugene, Braley, Hal, Davey, Gayle M., Mottram, Patricia, van de Velde, Nicholas, Jensen, Kent, Lew, Andrew M., Wright, Mark D., Heath, William R., Shortman, Ken, Lahoud, Mireille H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological and medical sciences CD4-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - metabolism Dendritic Cells - cytology Fundamental and applied biological sciences. Psychology Fundamental immunology Hematopoietic Stem Cells - cytology Humans Immunobiology Lectins, C-Type - chemistry Lectins, C-Type - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Modulation of the immune response (stimulation, suppression) Molecular Sequence Data Protein Structure, Tertiary Sequence Homology, Amino Acid Signal Transduction Vaccines - chemistry Vaccines - metabolism
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