The GPIIb/IIIa (integrin αIIbβ3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend

Starting 90 years ago with a clinical description by Glanzmann of a bleeding disorder associated with a defect in platelet function, technologic advances helped investigators identify the defect as a mutation(s) in the integrin family receptor, αIIbβ3, which has the capacity to bind fibrinogen (and...

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Veröffentlicht in:	Blood 2008-10, Vol.112 (8), p.3011-3025
Hauptverfasser:	Coller, Barry S., Shattil, Sanford J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ASH 50th Anniversary Review Biological and medical sciences Fibrinogen - metabolism Hematologic and hematopoietic diseases Hematology - history Hematology - methods History, 20th Century History, 21st Century Humans Medical Laboratory Science Medical sciences Platelet Aggregation Platelet Aggregation Inhibitors - pharmacology Platelet Glycoprotein GPIIb-IIIa Complex - chemistry Platelet Glycoprotein GPIIb-IIIa Complex - genetics Thrombasthenia - diagnosis Thrombasthenia - genetics
Online-Zugang:	Volltext
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