Impairment of NO-Dependent Relaxation in Intralobar Pulmonary Arteries: Comparison of Urban Particulate Matter and Manufactured Nanoparticles

Background and objectives: Because pulmonary circulation is the primary vascular target of inhaled particulate matter (PM), and nitric oxide is a major vasculoprotective agent, in this study we investigated the effect of various particles on the NO-cyclic guanosine monophosphate (cGMP) pathway in pu...

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Veröffentlicht in:	Environmental health perspectives 2008-10, Vol.116 (10), p.1294-1299
Hauptverfasser:	Courtois, Arnaud, Andujar, Pascal, Ladeiro, Yannick, Baudrimont, Isabelle, Delannoy, Estelle, Leblais, Véronique, Begueret, Hugues, Galland, Marie Annick Billon, Brochard, Patrick, Marano, Francelyne, Marthan, Roger, Muller, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Air Pollutants Air Pollutants - toxicity Analogue Animals Antioxidants Arteries Assessments Biochemistry, Molecular Biology Carbon black Cardiovascular diseases Cattle Cholinergic receptors Cytokines Dexamethasone Endothelial cells Endothelium Guanosines Health Health aspects Impairment In Vitro Techniques In vitro testing Inflammatory response Life Sciences Lungs Male Muscle Relaxation Muscle Relaxation - drug effects Nanoparticles Nitric Oxide Nitric Oxide - physiology Oxidative stress Pathways Pulmonary Artery Pulmonary Artery - drug effects Pulmonary Artery - physiology Pulmonary circulation Rats Rats, Wistar Reactive oxygen species Risk factors Titanium dioxide Tumors Ultrafines
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