Regulation of extracellular serotonin levels and brain-derived neurotrophic factor in rats with high and low exploratory activity

Abstract Serotonin (5-HT) system has a significant role in anxiety- and depression-related states and may be influenced by brain-derived neurotrophic factor (BDNF). This study examined extracellular 5-HT levels and expression of BDNF in rats with persistently low or high levels of exploratory activi...

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Veröffentlicht in:	Brain research 2008-02, Vol.1194 (5), p.110-117
Hauptverfasser:	Mällo, Tanel, Kõiv, Kadri, Koppel, Indrek, Raudkivi, Karita, Uustare, Ain, Rinken, Ago, Timmusk, Tõnis, Harro, Jaanus
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Anxiety Behavior, Animal - drug effects Behavioral psychophysiology Biological and medical sciences Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Citalopram - pharmacology Exploratory Behavior - drug effects Exploratory Behavior - physiology Exploratory behaviour Extracellular Fluid - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Hippocampus Individual differences Male Medial prefrontal cortex Neurology Neurotransmission and behavior Neurotrophins p-Chloroamphetamine - pharmacology Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Wistar Research Report RNA, Messenger - metabolism Serotonin - metabolism Serotonin Agents - pharmacology Serotonin transporter Serotonin Uptake Inhibitors - pharmacology
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