Deficit in a Neural Correlate of Reality Monitoring in Schizophrenia Patients

Patients who suffer from the devastating psychiatric illness schizophrenia are plagued by hallucinations, bizarre behavior, and delusional ideas, such as believing that they are controlled by malevolent outside forces. A fundamental human cognitive operation that may contribute to these hallmark sym...

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Veröffentlicht in:Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2008-11, Vol.18 (11), p.2532-2539
Hauptverfasser: Vinogradov, Sophia, Luks, Tracy L., Schulman, Brian J., Simpson, Gregory V.
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container_end_page 2539
container_issue 11
container_start_page 2532
container_title Cerebral cortex (New York, N.Y. 1991)
container_volume 18
creator Vinogradov, Sophia
Luks, Tracy L.
Schulman, Brian J.
Simpson, Gregory V.
description Patients who suffer from the devastating psychiatric illness schizophrenia are plagued by hallucinations, bizarre behavior, and delusional ideas, such as believing that they are controlled by malevolent outside forces. A fundamental human cognitive operation that may contribute to these hallmark symptoms is the ability to maintain accurate and coherent self-referential processing over time, such as occurs during reality monitoring (distinguishing self-generated from externally perceived information). However, the neural bases for a disturbance in this operation in schizophrenia have not been fully explored. Using functional magnetic resonance imaging, we asked clinically stable schizophrenia patients to remember whether or not they had generated a target word during an earlier sentence completion task. We found that, during accurate performance of this self-referential source memory task, the schizophrenia subjects manifest a deficit in rostral medial prefrontal cortex (mPFC) activity—a brain region critically implicated in both the instantiation and the retrieval of self-referential information in healthy subjects. Impairment in rostral mPFC function likely plays a key role in the profound subjective disturbances that characterize schizophrenia and that are the aspect of the disorder most troubling to patients and to society at large.
doi_str_mv 10.1093/cercor/bhn028
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source MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection
subjects Adult
agency
cognition
Cognition Disorders - physiopathology
Female
fMRI
Humans
Magnetic Resonance Imaging
Male
medial prefrontal cortex
Middle Aged
Prefrontal Cortex - physiopathology
Reality Testing
Recognition (Psychology) - physiology
Schizophrenia - physiopathology
Schizophrenic Psychology
Self Concept
self-referential processes
source memory
title Deficit in a Neural Correlate of Reality Monitoring in Schizophrenia Patients
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