Domain-Specific Regulation of Recombination in Caenorhabditis elegans in Response to Temperature, Age and Sex
It is generally considered that meiotic recombination rates increase with temperature, decrease with age, and differ between the sexes. We have reexamined the effects of these factors on meiotic recombination in the nematode Caenorhabditis elegans using physical markers that encompass >96% of chr...
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| Veröffentlicht in: | Genetics (Austin) 2008-10, Vol.180 (2), p.715-726 |
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| creator | Lim, Jaclyn G. Y Stine, Rachel R. W Yanowitz, Judith L |
| description | It is generally considered that meiotic recombination rates increase with temperature, decrease with age, and differ between the sexes. We have reexamined the effects of these factors on meiotic recombination in the nematode Caenorhabditis elegans using physical markers that encompass >96% of chromosome III. The only difference in overall crossover frequency between oocytes and male sperm was observed at 16 degrees . In addition, crossover interference (CI) differs between the germ lines, with oocytes displaying higher CI than male sperm. Unexpectedly, our analyses reveal significant changes in crossover distribution in the hermaphrodite oocyte in response to temperature. This feature appears to be a general feature of C. elegans chromosomes as similar changes in response to temperature are seen for the X chromosome. We also find that the distribution of crossovers changes with age in both hermaphrodites and females. Our observations indicate that it is the oocytes from the youngest mothers-and not the oldest-that showed a different pattern of crossovers. Our data enhance the emerging hypothesis that recombination in C. elegans, as in humans, is regulated in large chromosomal domains. |
| doi_str_mv | 10.1534/genetics.108.090142 |
| format | Article |
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Y ; Stine, Rachel R. W ; Yanowitz, Judith L</creator><creatorcontrib>Lim, Jaclyn G. Y ; Stine, Rachel R. W ; Yanowitz, Judith L</creatorcontrib><description>It is generally considered that meiotic recombination rates increase with temperature, decrease with age, and differ between the sexes. We have reexamined the effects of these factors on meiotic recombination in the nematode Caenorhabditis elegans using physical markers that encompass >96% of chromosome III. The only difference in overall crossover frequency between oocytes and male sperm was observed at 16 degrees . In addition, crossover interference (CI) differs between the germ lines, with oocytes displaying higher CI than male sperm. Unexpectedly, our analyses reveal significant changes in crossover distribution in the hermaphrodite oocyte in response to temperature. This feature appears to be a general feature of C. elegans chromosomes as similar changes in response to temperature are seen for the X chromosome. We also find that the distribution of crossovers changes with age in both hermaphrodites and females. Our observations indicate that it is the oocytes from the youngest mothers-and not the oldest-that showed a different pattern of crossovers. Our data enhance the emerging hypothesis that recombination in C. elegans, as in humans, is regulated in large chromosomal domains.</description><identifier>ISSN: 0016-6731</identifier><identifier>ISSN: 1943-2631</identifier><identifier>EISSN: 1943-2631</identifier><identifier>DOI: 10.1534/genetics.108.090142</identifier><identifier>PMID: 18780748</identifier><identifier>CODEN: GENTAE</identifier><language>eng</language><publisher>United States: Genetics Soc America</publisher><subject>Age ; Age Factors ; Animals ; Binding sites ; Caenorhabditis elegans - genetics ; Caenorhabditis elegans - physiology ; Chromosome Mapping ; Chromosomes ; Chromosomes - genetics ; Crossing Over, Genetic ; Environmental conditions ; Female ; Genes, Helminth ; Genetics ; Investigations ; Male ; Models, Genetic ; Oocytes - metabolism ; Proteins ; Recombination, Genetic ; Reproduction - genetics ; Reproduction - physiology ; Spermatocytes - metabolism ; Temperature ; X Chromosome</subject><ispartof>Genetics (Austin), 2008-10, Vol.180 (2), p.715-726</ispartof><rights>Copyright Genetics Society of America Oct 2008</rights><rights>Copyright © 2008 by the Genetics Society of America</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-8a219ceba9065e0207b0d1f5bfb53afd3d9224877d446fc6eb8436f0a58696d33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18780748$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lim, Jaclyn G. Y</creatorcontrib><creatorcontrib>Stine, Rachel R. W</creatorcontrib><creatorcontrib>Yanowitz, Judith L</creatorcontrib><title>Domain-Specific Regulation of Recombination in Caenorhabditis elegans in Response to Temperature, Age and Sex</title><title>Genetics (Austin)</title><addtitle>Genetics</addtitle><description>It is generally considered that meiotic recombination rates increase with temperature, decrease with age, and differ between the sexes. We have reexamined the effects of these factors on meiotic recombination in the nematode Caenorhabditis elegans using physical markers that encompass >96% of chromosome III. The only difference in overall crossover frequency between oocytes and male sperm was observed at 16 degrees . In addition, crossover interference (CI) differs between the germ lines, with oocytes displaying higher CI than male sperm. Unexpectedly, our analyses reveal significant changes in crossover distribution in the hermaphrodite oocyte in response to temperature. This feature appears to be a general feature of C. elegans chromosomes as similar changes in response to temperature are seen for the X chromosome. We also find that the distribution of crossovers changes with age in both hermaphrodites and females. Our observations indicate that it is the oocytes from the youngest mothers-and not the oldest-that showed a different pattern of crossovers. Our data enhance the emerging hypothesis that recombination in C. elegans, as in humans, is regulated in large chromosomal domains.</description><subject>Age</subject><subject>Age Factors</subject><subject>Animals</subject><subject>Binding sites</subject><subject>Caenorhabditis elegans - genetics</subject><subject>Caenorhabditis elegans - physiology</subject><subject>Chromosome Mapping</subject><subject>Chromosomes</subject><subject>Chromosomes - genetics</subject><subject>Crossing Over, Genetic</subject><subject>Environmental conditions</subject><subject>Female</subject><subject>Genes, Helminth</subject><subject>Genetics</subject><subject>Investigations</subject><subject>Male</subject><subject>Models, Genetic</subject><subject>Oocytes - metabolism</subject><subject>Proteins</subject><subject>Recombination, Genetic</subject><subject>Reproduction - genetics</subject><subject>Reproduction - physiology</subject><subject>Spermatocytes - metabolism</subject><subject>Temperature</subject><subject>X Chromosome</subject><issn>0016-6731</issn><issn>1943-2631</issn><issn>1943-2631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdUU1v1DAQtRAV3RZ-ARKKOHBqFn_FcS5I1VI-pEpIbTlbjjPOukrsYCcs_fd4tQuFnkYz8-a9mXkIvSZ4TSrG3_fgYXYmrQmWa9xgwukztCINZyUVjDxHK4yJKEXNyCk6S-keYyyaSr5Ap0TWEtdcrtD4MYza-fJ2AuOsM8UN9MugZxd8EWzOTBhb5w8F54uNBh_iVredm10qYIBe-7Tv3ECagk9QzKG4g3GCqOclwkVx2UOhfVfcwq-X6MTqIcGrYzxH3z9d3W2-lNffPn_dXF6Xhgsyl1JT0hhodYNFBZjiusUdsVVr24pp27GuoZTLuu44F9YIaCVnwmJdSdGIjrFz9OHAOy3tCJ0BP0c9qCm6UccHFbRT_3e826o-_FS0yu-qq0zw7kgQw48F0qxGlwwMg_YQlqSyTJ0fuFd6-wR4H5bo83GKEk4YZYJkEDuATAwpRbB_NyFY7b1Uf7zMBakOXuapN_8e8ThzNO9xya3rtzsXQaVRD0OGE7Xb7YjEiqo68_8G3l2roA</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Lim, Jaclyn G. 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Y ; Stine, Rachel R. W ; Yanowitz, Judith L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-8a219ceba9065e0207b0d1f5bfb53afd3d9224877d446fc6eb8436f0a58696d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Age</topic><topic>Age Factors</topic><topic>Animals</topic><topic>Binding sites</topic><topic>Caenorhabditis elegans - genetics</topic><topic>Caenorhabditis elegans - physiology</topic><topic>Chromosome Mapping</topic><topic>Chromosomes</topic><topic>Chromosomes - genetics</topic><topic>Crossing Over, Genetic</topic><topic>Environmental conditions</topic><topic>Female</topic><topic>Genes, Helminth</topic><topic>Genetics</topic><topic>Investigations</topic><topic>Male</topic><topic>Models, Genetic</topic><topic>Oocytes - metabolism</topic><topic>Proteins</topic><topic>Recombination, Genetic</topic><topic>Reproduction - genetics</topic><topic>Reproduction - physiology</topic><topic>Spermatocytes - metabolism</topic><topic>Temperature</topic><topic>X Chromosome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lim, Jaclyn G. 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Y</au><au>Stine, Rachel R. W</au><au>Yanowitz, Judith L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Domain-Specific Regulation of Recombination in Caenorhabditis elegans in Response to Temperature, Age and Sex</atitle><jtitle>Genetics (Austin)</jtitle><addtitle>Genetics</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>180</volume><issue>2</issue><spage>715</spage><epage>726</epage><pages>715-726</pages><issn>0016-6731</issn><issn>1943-2631</issn><eissn>1943-2631</eissn><coden>GENTAE</coden><abstract>It is generally considered that meiotic recombination rates increase with temperature, decrease with age, and differ between the sexes. We have reexamined the effects of these factors on meiotic recombination in the nematode Caenorhabditis elegans using physical markers that encompass >96% of chromosome III. The only difference in overall crossover frequency between oocytes and male sperm was observed at 16 degrees . In addition, crossover interference (CI) differs between the germ lines, with oocytes displaying higher CI than male sperm. Unexpectedly, our analyses reveal significant changes in crossover distribution in the hermaphrodite oocyte in response to temperature. This feature appears to be a general feature of C. elegans chromosomes as similar changes in response to temperature are seen for the X chromosome. We also find that the distribution of crossovers changes with age in both hermaphrodites and females. Our observations indicate that it is the oocytes from the youngest mothers-and not the oldest-that showed a different pattern of crossovers. Our data enhance the emerging hypothesis that recombination in C. elegans, as in humans, is regulated in large chromosomal domains.</abstract><cop>United States</cop><pub>Genetics Soc America</pub><pmid>18780748</pmid><doi>10.1534/genetics.108.090142</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Genetics (Austin), 2008-10, Vol.180 (2), p.715-726 |
| issn | 0016-6731 1943-2631 1943-2631 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Age Age Factors Animals Binding sites Caenorhabditis elegans - genetics Caenorhabditis elegans - physiology Chromosome Mapping Chromosomes Chromosomes - genetics Crossing Over, Genetic Environmental conditions Female Genes, Helminth Genetics Investigations Male Models, Genetic Oocytes - metabolism Proteins Recombination, Genetic Reproduction - genetics Reproduction - physiology Spermatocytes - metabolism Temperature X Chromosome |
| title | Domain-Specific Regulation of Recombination in Caenorhabditis elegans in Response to Temperature, Age and Sex |
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