Loss of DNA ligase IV prevents recognition of DNA by double-strand break repair proteins XRCC4 and XLF

The repair of DNA double-strand breaks by nonhomologous end-joining (NHEJ) is essential for maintenance of genomic integrity and cell viability. Central to the molecular mechanism of NHEJ is DNA ligase IV/XRCC4/XLF complex, which rejoins the DNA. During adenovirus (Ad5) infection, ligase IV is targe...

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Veröffentlicht in:	Nucleic acids research 2008-10, Vol.36 (18), p.5773-5786
Hauptverfasser:	Jayaram, Sumithra, Ketner, Gary, Adachi, Noritaka, Hanakahi, Les A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus Adenovirus E1B Proteins - metabolism Adenovirus E4 Proteins - metabolism Cell Line DNA - metabolism DNA Breaks, Double-Stranded DNA Ligase ATP DNA Ligases - genetics DNA Ligases - metabolism DNA Repair DNA Repair Enzymes - metabolism DNA-Binding Proteins - metabolism Genome Integrity, Repair and HeLa Cells Humans Mutation Protein Binding
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