Potential Role of High-Mobility Group Box 1 in Cystic Fibrosis Airway Disease

High-mobility group box 1 (HMGB1) is a potent inflammatory mediator elevated in sepsis and rheumatoid arthritis, although its role in cystic fibrosis (CF) lung disease is unknown. To determine whether HMGB1 contributes to CF lung inflammation, including neutrophil chemotaxis and lung matrix degradat...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2008-10, Vol.178 (8), p.822-831
Hauptverfasser:	Rowe, Steven M, Jackson, Patricia L, Liu, Gang, Hardison, Mathew, Livraghi, Alessandra, Solomon, G. Martin, McQuaid, D. Brent, Noerager, Brett D, Gaggar, Amit, Clancy, J. P, O'Neal, Wanda, Sorscher, Eric J, Abraham, Edward, Blalock, J. Edwin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Blotting, Western Bronchoalveolar Lavage Fluid - chemistry C. Cystic Fibrosis Chemotaxis, Leukocyte - physiology Cystic Fibrosis - metabolism Disease Models, Animal Disease Progression Emergency and intensive respiratory care Enzyme-Linked Immunosorbent Assay Female HMGB1 Protein - biosynthesis Humans Intensive care medicine Male Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C3H Neutrophils - metabolism Spectrometry, Mass, Electrospray Ionization Sputum - metabolism
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