Synthesis of Novel Caspase Inhibitors for Characterization of the Active Caspase Proteome in Vitro and in Vivo

Caspases are cysteine proteases that are essential for cytokine maturation and apoptosis. To facilitate the dissection of caspase function in vitro and in vivo, we have synthesized irreversible caspase inhibitors with biotin attached via linker arms of various lengths (12a−d) and a 2,4-dinitrophenyl...

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Veröffentlicht in:	Journal of medicinal chemistry 2006-12, Vol.49 (26), p.7636-7645
Hauptverfasser:	Henzing, Alexander J, Dodson, Helen, Reid, Joel M, Kaufmann, Scott H, Baxter, Robert L, Earnshaw, William C
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Labels Analytical, structural and metabolic biochemistry Apoptosis - drug effects Biological and medical sciences Caspase 6 - metabolism Caspase Inhibitors Chromatography, Affinity Cysteine Proteinase Inhibitors - chemical synthesis Cysteine Proteinase Inhibitors - pharmacology Enzyme Activation - drug effects Enzyme Precursors - chemistry Flow Cytometry Fundamental and applied biological sciences. Psychology General aspects, investigation methods Humans Immunoblotting In Vitro Techniques Jurkat Cells - drug effects Proteins Proteome Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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