Inflammatory biomarkers, disease activity and spinal disease measures in patients with ankylosing spondylitis after treatment with infliximab

Objective:To evaluate the relationship between biomarker levels and disease activity and the spinal inflammation detected by magnetic resonance imaging (MRI) in patients with ankylosing spondylitis (AS).Methods:Patients with AS were randomly assigned in a 3:8 ratio to receive infusions of placebo or...

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Veröffentlicht in:	Annals of the rheumatic diseases 2008-04, Vol.67 (4), p.511-517
Hauptverfasser:	Visvanathan, S, Wagner, C, Marini, J C, Baker, D, Gathany, T, Han, J, van der Heijde, D, Braun, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - therapeutic use Antirheumatic Agents - therapeutic use Biological and medical sciences Biomarkers Biomarkers - blood C-Reactive Protein - metabolism Cytokines Disease Diseases of the osteoarticular system Diseases of the spine Extended Reports Female Health risk assessment Humans Immunomodulators Inflammation Inflammatory joint diseases Infliximab Interleukin-6 - blood Magnetic Resonance Imaging Male Medical sciences NMR Nuclear magnetic resonance Pathogenesis Pharmacology. Drug treatments Predictive Value of Tests R&D Research & development Rheumatoid arthritis Severity of Illness Index Spondylitis, Ankylosing - blood Spondylitis, Ankylosing - drug therapy Studies Treatment Outcome Tumor necrosis factor-TNF Validity Vascular endothelial growth factor Vascular Endothelial Growth Factor A - blood
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