Critical care in the emergency department: severe sepsis and septic shock
Severe sepsis is a common and commonly fatal disease and is essentially an exaggerated inflammatory response. The epidemiology of severe sepsis and septic shock has been difficult to determine because of an inconsistent approach to definitions and diagnosis. Patients with sepsis account for approxim...
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| Veröffentlicht in: | Emergency medicine journal : EMJ 2006-09, Vol.23 (9), p.713-717 |
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| description | Severe sepsis is a common and commonly fatal disease and is essentially an exaggerated inflammatory response. The epidemiology of severe sepsis and septic shock has been difficult to determine because of an inconsistent approach to definitions and diagnosis. Patients with sepsis account for approximately a third of hospital and intensive care unit bed days in the UK and mortality ranges from 25% to 80%. A number of interventions have recently been shown to improve outcomes. The Surviving Sepsis Campaign recommends a package of evidence based interventions known as the sepsis resuscitation bundles and the sepsis treatment bundles. The aim is to ensure that eligible patients receive all appropriate treatments in a timely fashion, utilising protocol driven prescriptions. |
| doi_str_mv | 10.1136/emj.2005.029934 |
| format | Article |
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The epidemiology of severe sepsis and septic shock has been difficult to determine because of an inconsistent approach to definitions and diagnosis. Patients with sepsis account for approximately a third of hospital and intensive care unit bed days in the UK and mortality ranges from 25% to 80%. A number of interventions have recently been shown to improve outcomes. The Surviving Sepsis Campaign recommends a package of evidence based interventions known as the sepsis resuscitation bundles and the sepsis treatment bundles. 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The epidemiology of severe sepsis and septic shock has been difficult to determine because of an inconsistent approach to definitions and diagnosis. Patients with sepsis account for approximately a third of hospital and intensive care unit bed days in the UK and mortality ranges from 25% to 80%. A number of interventions have recently been shown to improve outcomes. The Surviving Sepsis Campaign recommends a package of evidence based interventions known as the sepsis resuscitation bundles and the sepsis treatment bundles. The aim is to ensure that eligible patients receive all appropriate treatments in a timely fashion, utilising protocol driven prescriptions.</description><subject>Aged</subject><subject>An Occasional Series on Critical Care</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Catheterization, Central Venous</subject><subject>central venous oxygen saturation</subject><subject>central venous pressure</subject><subject>Critical Care - methods</subject><subject>Critical Care - standards</subject><subject>CVP</subject><subject>Cytokines</subject><subject>Disease</subject><subject>DO2</subject><subject>early goal directed therapy</subject><subject>EGDT</subject><subject>emergency department</subject><subject>Emergency Medicine - methods</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fluids</subject><subject>GCS</subject><subject>Glasgow Coma Scale</subject><subject>Hospitals</subject><subject>Humans</subject><subject>ICU</subject><subject>Incidence</subject><subject>Infections</subject><subject>Intensive care</subject><subject>intensive care unit</subject><subject>intravenous</subject><subject>length of stay</subject><subject>LOS</subject><subject>mean arterial pressure</subject><subject>Medical prognosis</subject><subject>mixed venous oxygen saturation</subject><subject>Mortality</subject><subject>Ostomy</subject><subject>Oxygen - metabolism</subject><subject>oxygen consumption</subject><subject>oxygen delivery</subject><subject>Practice Guidelines as Topic</subject><subject>pulmonary artery</subject><subject>recombinant human activated protein C</subject><subject>RhAPC</subject><subject>ScvO2</subject><subject>Sepsis</subject><subject>Sepsis - diagnosis</subject><subject>Sepsis - epidemiology</subject><subject>Sepsis - metabolism</subject><subject>Sepsis - physiopathology</subject><subject>Sepsis - therapy</subject><subject>septic shock</subject><subject>Shock, Septic - therapy</subject><subject>SIRS</subject><subject>Survival Analysis</subject><subject>SvO2</subject><subject>systemic inflammatory response syndrome</subject><subject>Treatment Outcome</subject><subject>Ulcers</subject><subject>United Kingdom - epidemiology</subject><subject>United States - epidemiology</subject><subject>VO2</subject><issn>1472-0205</issn><issn>1472-0213</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqFkctv1DAQxi0Eog84c0ORkHpAynb8TjggVQstlUK5AOJmOc6k620ei52t2v8er7JaHhdOHml-8803_gh5RWFBKVfn2K8XDEAugJUlF0_IMRWa5cAof3qoQR6RkxjXAFSWonhOjqgqGYWiPCbXy-An72yXORsw80M2rTDDHsMtDu4xa3Bjw9TjML3LIt5jYiJuoo-ZHZpdmYazuBrd3QvyrLVdxJf795R8u_z4dfkpr75cXS8vqrwWJZty51opQdIGucCm0LZkWLS6BaWbVrTgatUwrRznOpkVFpluJa9rJpRy1gI_Je9n3c227rFxyVqwndkE39vwaEbrzd-dwa_M7XhvmFSCsZ3A2V4gjD-3GCfT--iw6-yA4zYaVWhVCqYS-OYfcD1uw5COM1QXAKCZ4Ik6nykXxhgDtgcrFMwuJJNCMruQzBxSmnj95wW_-X0qCchnwMcJHw59G-6M0ulfzM33pWGfb2RV_fhgqsS_nfk6bfrf9l9PBao3</recordid><startdate>200609</startdate><enddate>200609</enddate><creator>Nee, P A</creator><general>BMJ Publishing Group Ltd and the British Association for Accident & Emergency Medicine</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RQ</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>U9A</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200609</creationdate><title>Critical care in the emergency department: severe sepsis and septic shock</title><author>Nee, P A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b492t-ccf55051de34ed87a92e8f7f067df4f0cb6d276c3375944ae27f53bb2466caa03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>An Occasional Series on Critical Care</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Catheterization, Central Venous</topic><topic>central venous oxygen saturation</topic><topic>central venous pressure</topic><topic>Critical Care - methods</topic><topic>Critical Care - standards</topic><topic>CVP</topic><topic>Cytokines</topic><topic>Disease</topic><topic>DO2</topic><topic>early goal directed therapy</topic><topic>EGDT</topic><topic>emergency department</topic><topic>Emergency Medicine - methods</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fluids</topic><topic>GCS</topic><topic>Glasgow Coma Scale</topic><topic>Hospitals</topic><topic>Humans</topic><topic>ICU</topic><topic>Incidence</topic><topic>Infections</topic><topic>Intensive care</topic><topic>intensive care unit</topic><topic>intravenous</topic><topic>length of stay</topic><topic>LOS</topic><topic>mean arterial pressure</topic><topic>Medical prognosis</topic><topic>mixed venous oxygen saturation</topic><topic>Mortality</topic><topic>Ostomy</topic><topic>Oxygen - metabolism</topic><topic>oxygen consumption</topic><topic>oxygen delivery</topic><topic>Practice Guidelines as Topic</topic><topic>pulmonary artery</topic><topic>recombinant human activated protein C</topic><topic>RhAPC</topic><topic>ScvO2</topic><topic>Sepsis</topic><topic>Sepsis - diagnosis</topic><topic>Sepsis - epidemiology</topic><topic>Sepsis - metabolism</topic><topic>Sepsis - physiopathology</topic><topic>Sepsis - therapy</topic><topic>septic shock</topic><topic>Shock, Septic - therapy</topic><topic>SIRS</topic><topic>Survival Analysis</topic><topic>SvO2</topic><topic>systemic inflammatory response syndrome</topic><topic>Treatment Outcome</topic><topic>Ulcers</topic><topic>United Kingdom - epidemiology</topic><topic>United States - epidemiology</topic><topic>VO2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nee, P A</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Career & Technical Education Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Emergency medicine journal : EMJ</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nee, P A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Critical care in the emergency department: severe sepsis and septic shock</atitle><jtitle>Emergency medicine journal : EMJ</jtitle><addtitle>Emerg Med J</addtitle><date>2006-09</date><risdate>2006</risdate><volume>23</volume><issue>9</issue><spage>713</spage><epage>717</epage><pages>713-717</pages><issn>1472-0205</issn><eissn>1472-0213</eissn><abstract>Severe sepsis is a common and commonly fatal disease and is essentially an exaggerated inflammatory response. The epidemiology of severe sepsis and septic shock has been difficult to determine because of an inconsistent approach to definitions and diagnosis. Patients with sepsis account for approximately a third of hospital and intensive care unit bed days in the UK and mortality ranges from 25% to 80%. A number of interventions have recently been shown to improve outcomes. The Surviving Sepsis Campaign recommends a package of evidence based interventions known as the sepsis resuscitation bundles and the sepsis treatment bundles. The aim is to ensure that eligible patients receive all appropriate treatments in a timely fashion, utilising protocol driven prescriptions.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and the British Association for Accident & Emergency Medicine</pub><pmid>16921089</pmid><doi>10.1136/emj.2005.029934</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Emergency medicine journal : EMJ, 2006-09, Vol.23 (9), p.713-717 |
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| source | MEDLINE; BMJ Journals - NESLi2; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Aged An Occasional Series on Critical Care Anti-Bacterial Agents - therapeutic use Catheterization, Central Venous central venous oxygen saturation central venous pressure Critical Care - methods Critical Care - standards CVP Cytokines Disease DO2 early goal directed therapy EGDT emergency department Emergency Medicine - methods Epidemiology Female Fluids GCS Glasgow Coma Scale Hospitals Humans ICU Incidence Infections Intensive care intensive care unit intravenous length of stay LOS mean arterial pressure Medical prognosis mixed venous oxygen saturation Mortality Ostomy Oxygen - metabolism oxygen consumption oxygen delivery Practice Guidelines as Topic pulmonary artery recombinant human activated protein C RhAPC ScvO2 Sepsis Sepsis - diagnosis Sepsis - epidemiology Sepsis - metabolism Sepsis - physiopathology Sepsis - therapy septic shock Shock, Septic - therapy SIRS Survival Analysis SvO2 systemic inflammatory response syndrome Treatment Outcome Ulcers United Kingdom - epidemiology United States - epidemiology VO2 |
| title | Critical care in the emergency department: severe sepsis and septic shock |
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