Decreased Urinary Beta-Defensin-1 Expression as a Biomarker of Response to Arsenic

Ingestion of arsenic (As) through contaminated drinking water results in increased risks of skin, lung, kidney, and bladder cancers. Due to its association with kidney and bladder cancers, we hypothesized that analysis of the urinary proteome could provide insight into the mechanisms of As toxicity....

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Veröffentlicht in:	Toxicological sciences 2008-11, Vol.106 (1), p.74-82
Hauptverfasser:	Hegedus, Christine M., Skibola, Christine F., Warner, Marcella, Skibola, Danica R., Alexander, David, Lim, Sophia, Dangleben, Nygerma L., Zhang, Luoping, Clark, Michael, Pfeiffer, Ruth M., Steinmaus, Craig, Smith, Allan H., Smith, Martyn T., Moore, Lee E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult arsenic Arsenic - adverse effects Arsenic - toxicity Arsenites - toxicity beta-Defensins - genetics beta-Defensins - urine Biomarkers - urine Carcinogenicity Chile Cross-Sectional Studies Dose-Response Relationship, Drug Down-Regulation Environmental Monitoring Female HeLa Cells human beta-defensin-1 Humans Male Micronuclei, Chromosome-Defective - chemically induced Nevada Protein Array Analysis proteomics Proteomics - methods Reproducibility of Results RNA, Messenger - metabolism SELDI-TOF MS Sodium Compounds - toxicity Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Urinary Bladder - drug effects Urinary Bladder - pathology Water Pollutants, Chemical - adverse effects Water Pollutants, Chemical - toxicity Young Adult
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