Glutamate-induced losses of oligodendrocytes and neurons and activation of caspase-3 in the rat spinal cord

Abstract The toxicity of released glutamate contributes substantially to secondary cell death following spinal cord injury (SCI). In this work, the extent and time courses of glutamate-induced losses of neurons and oligodendrocytes are established. Glutamate was administered into the spinal cords of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2008-06, Vol.153 (4), p.1034-1047
Hauptverfasser:	Xu, G.-Y, Liu, S, Hughes, M.G, McAdoo, D.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis Biological and medical sciences Caspase 3 - metabolism caspase-3 Cell Count Cell Death - drug effects Cytoskeletal Proteins - metabolism Dose-Response Relationship, Drug Enzyme Activation - drug effects Enzyme-Linked Immunosorbent Assay - methods excitotoxicity Fundamental and applied biological sciences. Psychology Glutamic Acid - pharmacology In Situ Nick-End Labeling - methods Male microdialysis Neurofilament Proteins - metabolism Neurology Neurons - drug effects Neurons - metabolism nuclear localization Oligodendroglia - drug effects Oligodendroglia - metabolism Phosphopyruvate Hydratase - metabolism Rats Rats, Sprague-Dawley Spinal Cord - cytology spinal cord injury Time Factors Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!