Role of the p38 Mitogen-Activated Protein Kinase/Cytosolic Phospholipase A2 Signaling Pathway in Blood—Brain Barrier Disruption after Focal Cerebral Ischemia and Reperfusion

Cytosolic phospholipase A2 (cPLA2) is a key enzyme that mediates arachidonic acid metabolism, which causes cerebral ischemia-induced oxidative injury, blood—brain barrier (BBB) dysfunction, and edema. Recent reports have shown that p38 mitogen—activated protein kinase (MAPK) is related to phosphoryl...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2008-10, Vol.28 (10), p.1686-1696
Hauptverfasser:	Nito, Chikako, Kamada, Hiroshi, Endo, Hidenori, Niizuma, Kuniyasu, Myer, D Jeannie, Chan, Pak H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Biological and medical sciences Blood-Brain Barrier - physiology Brain Edema - metabolism Brain Edema - pathology Brain Ischemia - metabolism Brain Ischemia - pathology Cerebral Infarction - metabolism Cerebral Infarction - pathology Cyclooxygenase 2 - metabolism Enzyme Inhibitors - pharmacology Humans Imidazoles - pharmacology Male Medical sciences Neurology Neuropharmacology Neuroprotective agent Oxidative Stress - physiology p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Pharmacology. Drug treatments Phospholipases A2, Cytosolic - metabolism Phosphorylation Pyridines - pharmacology Rats Rats, Sprague-Dawley Reperfusion Injury - metabolism Reperfusion Injury - pathology Signal Transduction - physiology Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Superoxide Dismutase-1 Superoxides - metabolism Vascular diseases and vascular malformations of the nervous system
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