The Palau early psychosis study: Distribution of cases by level of genetic risk

The Palau Early Psychosis Study (PEPS) was designed to examine the pathogenesis of early psychosis in a high‐risk population isolate. This paper describes the characteristics of our community‐based, non‐help seeking sample of 404 Palauan adolescents and quantifies the presence of early psychosis by...

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Veröffentlicht in:American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2007-01, Vol.144B (1), p.5-9
Hauptverfasser: Myles-Worsley, Marina, Blailes, Francisca, Ord, Lisa M., Weaver, Starla, Dever, Gregory, Faraone, Stephen V.
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container_title American journal of medical genetics. Part B, Neuropsychiatric genetics
container_volume 144B
creator Myles-Worsley, Marina
Blailes, Francisca
Ord, Lisa M.
Weaver, Starla
Dever, Gregory
Faraone, Stephen V.
description The Palau Early Psychosis Study (PEPS) was designed to examine the pathogenesis of early psychosis in a high‐risk population isolate. This paper describes the characteristics of our community‐based, non‐help seeking sample of 404 Palauan adolescents and quantifies the presence of early psychosis by level of genetic risk. The sample included 53 offspring of a schizophrenic parent designated as “Genetically Highest Risk” (GHR+) and 68 nieces/nephews of sib‐pairs/trios, designated as “Genetically High Risk” (GHR). The remaining subjects were recruited through a high school survey that identified 62 “Genetically Moderate Risk” (GMR) adolescents with an affected second or third degree relative and 221 “Genetically Low Risk” (GLR) subjects with no close affected relatives. The GLR adolescents included 117 symptomatic or “Clinically High Risk” (CHR) adolescents and 104 asymptomatic normal controls. Based on a modified K‐SADS‐PL assessment, we identified 221 adolescents with early psychosis, 62 or 28% of whom had already transitioned to a psychotic disorder. Together, the two highest risk groups contributed 31% of the adolescent‐onset psychosis cases and 27% of the prodromals. More than half of the early psychosis cases (53%) were GLR adolescents. The mean age of onset for DSM‐IV psychosis was 12.9 years, and males transitioned at an earlier age than females. Our results indicate that Palauan adolescents, even GLR adolescents with no close affected relatives, have elevated rates of early psychosis. These young subjects can contribute valuable information about the familial transmission of schizophrenia, the developmental course of the illness, and rates of transition to frank psychosis. © 2006 Wiley‐Liss, Inc.
doi_str_mv 10.1002/ajmg.b.30362
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Together, the two highest risk groups contributed 31% of the adolescent‐onset psychosis cases and 27% of the prodromals. More than half of the early psychosis cases (53%) were GLR adolescents. The mean age of onset for DSM‐IV psychosis was 12.9 years, and males transitioned at an earlier age than females. Our results indicate that Palauan adolescents, even GLR adolescents with no close affected relatives, have elevated rates of early psychosis. 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subjects Adolescent
adolescents
Adult and adolescent clinical studies
Age of Onset
Biological and medical sciences
Child
clinical high risk
Female
General aspects. Genetic counseling
genetic high risk
Genetic Predisposition to Disease
Humans
Male
Medical genetics
Medical sciences
Palau - epidemiology
Pedigree
prodromal symptoms
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Psychotic Disorders - epidemiology
Psychotic Disorders - genetics
Risk Factors
Schizophrenia
Schizophrenia - epidemiology
Schizophrenia - genetics
title The Palau early psychosis study: Distribution of cases by level of genetic risk
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