Opposing actions of 5HT1A and 5HT2-like serotonin receptors on modulations of the electric signal waveform in the electric fish Brachyhypopomus pinnicaudatus
Serotonin (5-HT) is an indirect modulator of the electric organ discharge (EOD) in the weakly electric gymnotiform fish, Brachyhypopomus pinnicaudatus. Injections of 5-HT enhance EOD waveform "masculinity", increasing both waveform amplitude and the duration of the second phase. This study...
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| Veröffentlicht in: | Hormones and behavior 2008-03, Vol.53 (3), p.481-488 |
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| creator | Allee, Susan J Markham, Michael R Salazar, Vielka L Stoddard, Philip K |
| description | Serotonin (5-HT) is an indirect modulator of the electric organ discharge (EOD) in the weakly electric gymnotiform fish, Brachyhypopomus pinnicaudatus. Injections of 5-HT enhance EOD waveform "masculinity", increasing both waveform amplitude and the duration of the second phase. This study investigated the pharmacological identity of 5-HT receptors that regulate the electric waveform and their effects on EOD amplitude and duration. We present evidence that two sets of serotonin receptors modulate the EOD in opposite directions. We found that the 5HT1AR agonist 8-OH-DPAT diminishes EOD duration and amplitude while the 5HT1AR antagonist WAY100635 increases these parameters. In contrast, the 5HT2R agonist alpha-Me-5-HT increases EOD amplitude but not duration, yet 5-HT-induced increases in EOD duration can be inhibited by blocking 5HT2A/2C-like receptors with ketanserin. These results show that 5-HT exerts bi-directional control of EOD modulations in B. pinnicaudatus via action at receptors similar to mammalian 5HT1A and 5HT2 receptors. The discordant amplitude and duration response suggests separate mechanisms for modulating these waveform parameters. |
| doi_str_mv | 10.1016/j.yhbeh.2007.12.001 |
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Injections of 5-HT enhance EOD waveform "masculinity", increasing both waveform amplitude and the duration of the second phase. This study investigated the pharmacological identity of 5-HT receptors that regulate the electric waveform and their effects on EOD amplitude and duration. We present evidence that two sets of serotonin receptors modulate the EOD in opposite directions. We found that the 5HT1AR agonist 8-OH-DPAT diminishes EOD duration and amplitude while the 5HT1AR antagonist WAY100635 increases these parameters. In contrast, the 5HT2R agonist alpha-Me-5-HT increases EOD amplitude but not duration, yet 5-HT-induced increases in EOD duration can be inhibited by blocking 5HT2A/2C-like receptors with ketanserin. These results show that 5-HT exerts bi-directional control of EOD modulations in B. pinnicaudatus via action at receptors similar to mammalian 5HT1A and 5HT2 receptors. The discordant amplitude and duration response suggests separate mechanisms for modulating these waveform parameters.</description><identifier>ISSN: 0018-506X</identifier><identifier>EISSN: 1095-6867</identifier><identifier>DOI: 10.1016/j.yhbeh.2007.12.001</identifier><identifier>PMID: 18206154</identifier><language>eng</language><publisher>United States: Elsevier BV</publisher><subject>Analysis of Variance ; Animal behavior ; Animal Communication ; Animals ; Biochemistry ; Electric Fish - metabolism ; Electric Organ - drug effects ; Electric Organ - physiology ; Fish ; Male ; Neurotransmitters ; Receptor, Serotonin, 5-HT1A - metabolism ; Receptors, Serotonin, 5-HT2 - metabolism ; Serotonin 5-HT1 Receptor Agonists ; Serotonin 5-HT1 Receptor Antagonists ; Serotonin 5-HT2 Receptor Agonists ; Serotonin 5-HT2 Receptor Antagonists ; Serotonin Agents - pharmacology ; Sex Factors ; Social Behavior ; Social Dominance</subject><ispartof>Hormones and behavior, 2008-03, Vol.53 (3), p.481-488</ispartof><rights>Copyright © 2008 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3451-ad9a62fa26b5d7aa4bac3e0d7e02671e9d8a8baabc1e50f7c487751f8cca08ef3</citedby><cites>FETCH-LOGICAL-c3451-ad9a62fa26b5d7aa4bac3e0d7e02671e9d8a8baabc1e50f7c487751f8cca08ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18206154$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Allee, Susan J</creatorcontrib><creatorcontrib>Markham, Michael R</creatorcontrib><creatorcontrib>Salazar, Vielka L</creatorcontrib><creatorcontrib>Stoddard, Philip K</creatorcontrib><title>Opposing actions of 5HT1A and 5HT2-like serotonin receptors on modulations of the electric signal waveform in the electric fish Brachyhypopomus pinnicaudatus</title><title>Hormones and behavior</title><addtitle>Horm Behav</addtitle><description>Serotonin (5-HT) is an indirect modulator of the electric organ discharge (EOD) in the weakly electric gymnotiform fish, Brachyhypopomus pinnicaudatus. Injections of 5-HT enhance EOD waveform "masculinity", increasing both waveform amplitude and the duration of the second phase. This study investigated the pharmacological identity of 5-HT receptors that regulate the electric waveform and their effects on EOD amplitude and duration. We present evidence that two sets of serotonin receptors modulate the EOD in opposite directions. We found that the 5HT1AR agonist 8-OH-DPAT diminishes EOD duration and amplitude while the 5HT1AR antagonist WAY100635 increases these parameters. In contrast, the 5HT2R agonist alpha-Me-5-HT increases EOD amplitude but not duration, yet 5-HT-induced increases in EOD duration can be inhibited by blocking 5HT2A/2C-like receptors with ketanserin. These results show that 5-HT exerts bi-directional control of EOD modulations in B. pinnicaudatus via action at receptors similar to mammalian 5HT1A and 5HT2 receptors. The discordant amplitude and duration response suggests separate mechanisms for modulating these waveform parameters.</description><subject>Analysis of Variance</subject><subject>Animal behavior</subject><subject>Animal Communication</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Electric Fish - metabolism</subject><subject>Electric Organ - drug effects</subject><subject>Electric Organ - physiology</subject><subject>Fish</subject><subject>Male</subject><subject>Neurotransmitters</subject><subject>Receptor, Serotonin, 5-HT1A - metabolism</subject><subject>Receptors, Serotonin, 5-HT2 - metabolism</subject><subject>Serotonin 5-HT1 Receptor Agonists</subject><subject>Serotonin 5-HT1 Receptor Antagonists</subject><subject>Serotonin 5-HT2 Receptor Agonists</subject><subject>Serotonin 5-HT2 Receptor Antagonists</subject><subject>Serotonin Agents - pharmacology</subject><subject>Sex Factors</subject><subject>Social Behavior</subject><subject>Social Dominance</subject><issn>0018-506X</issn><issn>1095-6867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkd9qFDEUxoModq0-gSDBC-9mTDJ_krkR2mKtUOhNBe_CmcyZnawzyZjMVPZhfNdm7VKtEMg5Od_3keRHyFvOcs54_XGX74cWh1wwJnMucsb4M7LhrKmyWtXyOdmkE5VVrP5-Ql7FuEstr8ryJTnhSrA61Rvy-2aefbRuS8Es1rtIfU-rq1t-RsF1h0pko_2BNGLwi3fW0YAG58WHJHV08t06wqNzGZDiiGYJ1tBotw5G-gvusPdhosn7ZN7bONDzAGbYD_vZz35aI52tc9bA2sGyxtfkRQ9jxDfH_ZR8u_x8e3GVXd98-Xpxdp2Zoqx4Bl0DtehB1G3VSYCyBVMg6yQyUUuOTadAtQCt4VixXppSSVnxXhkDTGFfnJJPD7nz2k7YGXRLgFHPwU4Q9tqD1U8nzg566--0qGqumiYFfDgGBP9zxbjoyUaD4wgO_Rq1ZIUoCimS8P1_wp1fQ_qmqHlTqrSqg6h4EJngYwzYP96EM31gr3f6D3t9YK-50Altcr379xF_PUfYxT1dn7Fd</recordid><startdate>200803</startdate><enddate>200803</enddate><creator>Allee, Susan J</creator><creator>Markham, Michael R</creator><creator>Salazar, Vielka L</creator><creator>Stoddard, Philip K</creator><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200803</creationdate><title>Opposing actions of 5HT1A and 5HT2-like serotonin receptors on modulations of the electric signal waveform in the electric fish Brachyhypopomus pinnicaudatus</title><author>Allee, Susan J ; Markham, Michael R ; Salazar, Vielka L ; Stoddard, Philip K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3451-ad9a62fa26b5d7aa4bac3e0d7e02671e9d8a8baabc1e50f7c487751f8cca08ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Analysis of Variance</topic><topic>Animal behavior</topic><topic>Animal Communication</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Electric Fish - metabolism</topic><topic>Electric Organ - drug effects</topic><topic>Electric Organ - physiology</topic><topic>Fish</topic><topic>Male</topic><topic>Neurotransmitters</topic><topic>Receptor, Serotonin, 5-HT1A - metabolism</topic><topic>Receptors, Serotonin, 5-HT2 - metabolism</topic><topic>Serotonin 5-HT1 Receptor Agonists</topic><topic>Serotonin 5-HT1 Receptor Antagonists</topic><topic>Serotonin 5-HT2 Receptor Agonists</topic><topic>Serotonin 5-HT2 Receptor Antagonists</topic><topic>Serotonin Agents - pharmacology</topic><topic>Sex Factors</topic><topic>Social Behavior</topic><topic>Social Dominance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Allee, Susan J</creatorcontrib><creatorcontrib>Markham, Michael R</creatorcontrib><creatorcontrib>Salazar, Vielka L</creatorcontrib><creatorcontrib>Stoddard, Philip K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Hormones and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Allee, Susan J</au><au>Markham, Michael R</au><au>Salazar, Vielka L</au><au>Stoddard, Philip K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Opposing actions of 5HT1A and 5HT2-like serotonin receptors on modulations of the electric signal waveform in the electric fish Brachyhypopomus pinnicaudatus</atitle><jtitle>Hormones and behavior</jtitle><addtitle>Horm Behav</addtitle><date>2008-03</date><risdate>2008</risdate><volume>53</volume><issue>3</issue><spage>481</spage><epage>488</epage><pages>481-488</pages><issn>0018-506X</issn><eissn>1095-6867</eissn><abstract>Serotonin (5-HT) is an indirect modulator of the electric organ discharge (EOD) in the weakly electric gymnotiform fish, Brachyhypopomus pinnicaudatus. Injections of 5-HT enhance EOD waveform "masculinity", increasing both waveform amplitude and the duration of the second phase. This study investigated the pharmacological identity of 5-HT receptors that regulate the electric waveform and their effects on EOD amplitude and duration. We present evidence that two sets of serotonin receptors modulate the EOD in opposite directions. We found that the 5HT1AR agonist 8-OH-DPAT diminishes EOD duration and amplitude while the 5HT1AR antagonist WAY100635 increases these parameters. In contrast, the 5HT2R agonist alpha-Me-5-HT increases EOD amplitude but not duration, yet 5-HT-induced increases in EOD duration can be inhibited by blocking 5HT2A/2C-like receptors with ketanserin. These results show that 5-HT exerts bi-directional control of EOD modulations in B. pinnicaudatus via action at receptors similar to mammalian 5HT1A and 5HT2 receptors. 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| subjects | Analysis of Variance Animal behavior Animal Communication Animals Biochemistry Electric Fish - metabolism Electric Organ - drug effects Electric Organ - physiology Fish Male Neurotransmitters Receptor, Serotonin, 5-HT1A - metabolism Receptors, Serotonin, 5-HT2 - metabolism Serotonin 5-HT1 Receptor Agonists Serotonin 5-HT1 Receptor Antagonists Serotonin 5-HT2 Receptor Agonists Serotonin 5-HT2 Receptor Antagonists Serotonin Agents - pharmacology Sex Factors Social Behavior Social Dominance |
| title | Opposing actions of 5HT1A and 5HT2-like serotonin receptors on modulations of the electric signal waveform in the electric fish Brachyhypopomus pinnicaudatus |
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