Induction time measurement of barbital tolerance in mice given recurrent subhypnotic dosage of barbital

A procedure designed to estimate the degree of development of neuronal tolerance to barbiturates is described. With this technique, it has been shown that a subhypnotic (125 mg/kg) peritoneal dose of barbital sodium, given twice daily, over the course of either five or 10 consecutive days, can produ...

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Veröffentlicht in:	Journal of the National Medical Association 1982-12, Vol.74 (12), p.1183-1187
Hauptverfasser:	Risher, D L, Baccus, A L, Townsend, S W, Proctor, C D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Barbital - pharmacology Barbiturates - pharmacology Drug Administration Schedule Drug Tolerance Injections, Intraperitoneal Male Mice Mice, Inbred ICR Neurons - drug effects Original Communications Reflex - drug effects Time Factors
Online-Zugang:	Volltext
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