The pallial basal ganglia pathway modulates the behaviorally driven gene expression of the motor pathway

The discrete neural network for songbird vocal communication provides an effective system to study neural mechanisms of learned motor behaviors in vertebrates. This system consists of two pathways − a vocal motor pathway used to produce learned vocalizations and a vocal pallial basal ganglia loop us...

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Veröffentlicht in:The European journal of neuroscience 2007-04, Vol.25 (7), p.2145-2160
Hauptverfasser: Kubikova, Lubica, Turner, Elena A., Jarvis, Erich D.
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Turner, Elena A.
Jarvis, Erich D.
description The discrete neural network for songbird vocal communication provides an effective system to study neural mechanisms of learned motor behaviors in vertebrates. This system consists of two pathways − a vocal motor pathway used to produce learned vocalizations and a vocal pallial basal ganglia loop used to learn and modify the vocalizations. However, it is not clear how the loop exerts control over the motor pathway. To study the mechanism, we used expression of the neural activity‐induced gene ZENK (or egr‐1), which shows singing‐regulated expression in a social context‐dependent manner: high levels in both pathways when singing undirected and low levels in the lateral part of the loop and in the robust nucleus of the arcopallium (RA) of the motor pathway when singing directed to another animal. Here, we show that there are two parallel interactive parts within the pallial basal ganglia loop, lateral and medial, which modulate singing‐driven ZENK expression of the motor pathway nuclei RA and HVC, respectively. Within the loop, the striatal and pallial nuclei appear to have opposing roles; the striatal vocal nucleus lateral AreaX is required for high ZENK expression in its downstream nuclei, particularly during undirected singing, while the pallial vocal lateral magnocellular nucleus of the anterior nidopallium is required for lower expression, particularly during directed singing. These results suggest a dynamic molecular interaction between the basal ganglia pathway and the motor pathway during production of a learned motor behavior.
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source MEDLINE; Wiley Online Library All Journals
subjects Animals
Basal Ganglia - anatomy & histology
Basal Ganglia - pathology
Basal Ganglia - physiology
Early Growth Response Protein 1 - genetics
Early Growth Response Protein 1 - metabolism
Efferent Pathways - anatomy & histology
Efferent Pathways - pathology
Efferent Pathways - physiology
Finches
Fluorescent Dyes - metabolism
Gene Expression Regulation
immediate-early gene
Male
motor-driven gene expression
Regression Analysis
song
Vocalization, Animal - physiology
zebra finch
ZENK
title The pallial basal ganglia pathway modulates the behaviorally driven gene expression of the motor pathway
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