Cytoskeletal reorganization induced by engagement of the NG2 proteoglycan leads to cell spreading and migration

Cells expressing the NG2 proteoglycan can attach, spread, and migrate on surfaces coated with NG2 mAbs, demonstrating that engagement of NG2 can trigger the cytoskeletal rearrangements necessary for changes in cell morphology and motility. Engagement of different epitopes of the proteoglycan results...

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Veröffentlicht in:	Molecular biology of the cell 1999-10, Vol.10 (10), p.3373-3387
Hauptverfasser:	Fang, X, Burg, M A, Barritt, D, Dahlin-Huppe, K, Nishiyama, A, Stallcup, W B
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Antibodies, Monoclonal Antigens - genetics Antigens - immunology Antigens - metabolism Carrier Proteins - metabolism Cell Movement Cytoskeleton - metabolism Fluorescent Antibody Technique Humans Mice Microfilament Proteins - metabolism Mutation Proteoglycans - genetics Proteoglycans - immunology Proteoglycans - metabolism Rats Signal Transduction Transfection Tumor Cells, Cultured
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