Curcumin Inhibits the Proteasome Activity in Human Colon Cancer Cells In vitro and In vivo

Curcumin (diferuloylmethane) is the major active ingredient of turmeric (Curcuma longa) used in South Asian cuisine for centuries. Curcumin has been shown to inhibit the growth of transformed cells and to have a number of potential molecular targets. However, the essential molecular targets of curcu...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2008-09, Vol.68 (18), p.7283-7292
Hauptverfasser:	MILACIC, Vesna, BANERJEE, Sanjeev, LANDIS-PIWOWAR, Kristin R, SARKAR, Fazlul H, MAJUMDAR, Adhip P. N, DOU, Q. Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Caspase 3 - metabolism Caspase 7 - metabolism Cell Growth Processes - drug effects Colonic Neoplasms - drug therapy Colonic Neoplasms - enzymology Curcumin - pharmacology Dose-Response Relationship, Drug Female Gastroenterology. Liver. Pancreas. Abdomen HCT116 Cells Humans Leupeptins - pharmacology Medical sciences Mice Models, Molecular Pharmacology. Drug treatments Poly(ADP-ribose) Polymerases - metabolism Protease Inhibitors - pharmacology Proteasome Endopeptidase Complex - metabolism Proteasome Inhibitors Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors Xenograft Model Antitumor Assays
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